Quantitative assessment of cerebral hemodynamic parameters by QUASAR arterial spin labeling in alzheimer's disease and cognitively normal elderly adults at 3-Tesla

Henry K F Mak, Queenie Chan, Zhipeng Zhang, Esben T. Petersen, Deqiang Qiu, Linda Zhang, Kelvin K W Yau, Leung Wing Chu, Xavier Golay

Research output: Contribution to journalArticle

Abstract

QUASAR arterial spin labeling (ASL) was used to investigate the role of vascular impairment in Alzheimer's disease (AD). We hypothesized that the hemodynamic parameters monitoring cerebrovascular integrity, i.e., cerebral blood flow (CBF), arterial blood volume (aBV), and arterial transit time (aTT), would be affected. 13 AD patients and 15 healthy control (HC) subjects underwent 3T MRI scanning. Two separate blood flow acquisitions were obtained with 1 slice overlap for whole brain coverage. CBF, aBV, and aTT maps were calculated using in-house software. Preprocessing and statistical analyses were performed on SPM5. Region-of-interest (ROI) studies of ten selected cerebral regions were also conducted. There were significant differences in Mini Mental Status Exam (MMSE) (AD: 16.3 ± 4.55, HC: 28.5 ± 2.00) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) scores (AD: 25.25 ± 9.64, HC: 5.51 ± 2.62) between the 2 groups (p <0.001) but none in age (p = 0.068). CBF decreased significantly (p <0.01) in AD compared to controls in the right middle cingulate, left cuneus, left inferior and middle frontal, right superior frontal, left inferior parietal, and right supramarginal gyri. ROI studies confirmed significant hemodynamic impairments in AD compared to HC (p <0.05): CBF in middle and posterior cingulate, aBV in left superior temporal, right inferior parietal, and posterior cingulate, and aTT in left inferior frontal and middle cingulate gyri. CBF correlated positively while aTT correlated negatively to MMSE, and vice versa for ADAS-cog. Using QUASAR ASL, we found patterns of regional hemodynamic impairment typical of moderate AD, suggesting underlying vascular abnormality. As potential biomarkers, these hemodynamic parameters could differentiate patients from volunteers, and possibly indicate the conversion from healthy aging to mild cognitive impairment to AD.

Original languageEnglish (US)
Pages (from-to)33-44
Number of pages12
JournalJournal of Alzheimer's Disease
Volume31
Issue number1
DOIs
StatePublished - 2012
Externally publishedYes

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Cerebrovascular Circulation
Alzheimer Disease
Hemodynamics
Gyrus Cinguli
Blood Volume
Blood Vessels
Occipital Lobe
Parietal Lobe
Volunteers
Healthy Volunteers
Software
Biomarkers
Brain

Keywords

  • Alzheimer's disease
  • arterial blood volume
  • arterial spin labeling
  • arterial transit time
  • cerebral blood flow
  • magnetic resonance imaging
  • mild cognitive impairment
  • QUASAR

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Quantitative assessment of cerebral hemodynamic parameters by QUASAR arterial spin labeling in alzheimer's disease and cognitively normal elderly adults at 3-Tesla. / Mak, Henry K F; Chan, Queenie; Zhang, Zhipeng; Petersen, Esben T.; Qiu, Deqiang; Zhang, Linda; Yau, Kelvin K W; Chu, Leung Wing; Golay, Xavier.

In: Journal of Alzheimer's Disease, Vol. 31, No. 1, 2012, p. 33-44.

Research output: Contribution to journalArticle

Mak, Henry K F ; Chan, Queenie ; Zhang, Zhipeng ; Petersen, Esben T. ; Qiu, Deqiang ; Zhang, Linda ; Yau, Kelvin K W ; Chu, Leung Wing ; Golay, Xavier. / Quantitative assessment of cerebral hemodynamic parameters by QUASAR arterial spin labeling in alzheimer's disease and cognitively normal elderly adults at 3-Tesla. In: Journal of Alzheimer's Disease. 2012 ; Vol. 31, No. 1. pp. 33-44.
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AU - Petersen, Esben T.

AU - Qiu, Deqiang

AU - Zhang, Linda

AU - Yau, Kelvin K W

AU - Chu, Leung Wing

AU - Golay, Xavier

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