Quantitative assessment of atrial regional function using motion estimation computed tomography

Hiroshi Ashikaga, Jochen Cammin, Qiulin Tang, Karly Knudsen, Yuko Inoue, Elliot K. Fishman, Katsuyuki Taguchi

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: We validated a novel image-based motion estimation computed tomographic (CT) technique (iME) to quantify atrial regional function in swine in vivo. MATERIALS AND METHODS: Domestic swine (n = 8) underwent CT scan with intravenous contrast before and after median sternotomy where 15 to 30 glass beads were sutured to the atria to calculate the motion estimation error. Four-dimensional motion vector field was estimated using iME. Area change ratio (%AC) was calculated over the atrial endocardium to assess the surface deformation. RESULTS: The error between the measured and the calculated coordinates based on motion vector field was 0.76 ± 0.43 mm. The %AC was regionally heterogeneous. The %AC time course was significantly different between the right and the left atriums (P <0.001) as well as between the right atrial appendage and the right atrial chamber (P = 0.004). CONCLUSIONS: Quantitative assessment of atrial regional function using iME is highly accurate. Image-based motion estimation computed tomographic (CT) technique can quantify subtle regional dysfunction that is not apparent in global functional indices such as ejection fraction.

Original languageEnglish (US)
JournalJournal of Computer Assisted Tomography
DOIs
StateAccepted/In press - Jun 30 2014
Externally publishedYes

Fingerprint

Atrial Function
Tomography
Heart Atria
Swine
Endocardium
Atrial Appendage
Sternotomy
Glass

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Quantitative assessment of atrial regional function using motion estimation computed tomography. / Ashikaga, Hiroshi; Cammin, Jochen; Tang, Qiulin; Knudsen, Karly; Inoue, Yuko; Fishman, Elliot K.; Taguchi, Katsuyuki.

In: Journal of Computer Assisted Tomography, 30.06.2014.

Research output: Contribution to journalArticle

Ashikaga, Hiroshi ; Cammin, Jochen ; Tang, Qiulin ; Knudsen, Karly ; Inoue, Yuko ; Fishman, Elliot K. ; Taguchi, Katsuyuki. / Quantitative assessment of atrial regional function using motion estimation computed tomography. In: Journal of Computer Assisted Tomography. 2014.
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AU - Cammin, Jochen

AU - Tang, Qiulin

AU - Knudsen, Karly

AU - Inoue, Yuko

AU - Fishman, Elliot K.

AU - Taguchi, Katsuyuki

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N2 - OBJECTIVES: We validated a novel image-based motion estimation computed tomographic (CT) technique (iME) to quantify atrial regional function in swine in vivo. MATERIALS AND METHODS: Domestic swine (n = 8) underwent CT scan with intravenous contrast before and after median sternotomy where 15 to 30 glass beads were sutured to the atria to calculate the motion estimation error. Four-dimensional motion vector field was estimated using iME. Area change ratio (%AC) was calculated over the atrial endocardium to assess the surface deformation. RESULTS: The error between the measured and the calculated coordinates based on motion vector field was 0.76 ± 0.43 mm. The %AC was regionally heterogeneous. The %AC time course was significantly different between the right and the left atriums (P <0.001) as well as between the right atrial appendage and the right atrial chamber (P = 0.004). CONCLUSIONS: Quantitative assessment of atrial regional function using iME is highly accurate. Image-based motion estimation computed tomographic (CT) technique can quantify subtle regional dysfunction that is not apparent in global functional indices such as ejection fraction.

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