TY - JOUR
T1 - Quantitative anatomic measures and comorbid medical illness in late- life major depression
AU - Kumar, A.
AU - Miller, D.
AU - Ewbank, D.
AU - Yousem, D.
AU - Newberg, A.
AU - Samuels, S.
AU - Cowell, P.
AU - Gottlieb, G.
N1 - Funding Information:
This work was supported by a Clinical Mental Health Academic Award (AK) and Grant MH-52129 from the National Institute of Mental Health, The Alzheimer Disease Center Core (ADCC) and Grant KO1 AG 0058 from the National Institute on Aging, and a grant from the Charles A. Dana Foundation.
PY - 1997
Y1 - 1997
N2 - The authors examined the individual and relative roles of atrophy, comorbid medical illness, and cerebrovascular risk factors in the pathogenesis of late-life major depressive disorder (MDD). They used magnetic resonance imaging techniques to study 28 subjects with late-life MDD, 29 healthy control subjects, and 34 subjects with probable dementia of the Alzheimer type (DAT). Depressed subjects showed increases in cerebrospinal fluid volumes comparable to the DAT group but significantly different from control subjects. High-intensity signals, but not measures of atrophy correlated significantly with cerebrovascular risk factor scores. A logistic regression revealed that both brain atrophy and medical illness are associated with an increased risk of developing MDD. Data suggest that both atrophy and comorbid medical illness increase the likelihood of developing MDD in late life.
AB - The authors examined the individual and relative roles of atrophy, comorbid medical illness, and cerebrovascular risk factors in the pathogenesis of late-life major depressive disorder (MDD). They used magnetic resonance imaging techniques to study 28 subjects with late-life MDD, 29 healthy control subjects, and 34 subjects with probable dementia of the Alzheimer type (DAT). Depressed subjects showed increases in cerebrospinal fluid volumes comparable to the DAT group but significantly different from control subjects. High-intensity signals, but not measures of atrophy correlated significantly with cerebrovascular risk factor scores. A logistic regression revealed that both brain atrophy and medical illness are associated with an increased risk of developing MDD. Data suggest that both atrophy and comorbid medical illness increase the likelihood of developing MDD in late life.
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U2 - 10.1097/00019442-199700510-00003
DO - 10.1097/00019442-199700510-00003
M3 - Article
C2 - 9169241
AN - SCOPUS:85045588256
SN - 1064-7481
VL - 5
SP - 15
EP - 25
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 1
ER -