Quantitative anatomic measures and comorbid medical illness in late- life major depression

A. Kumar, D. Miller, D. Ewbank, David Mark Yousem, A. Newberg, S. Samuels, P. Cowell, G. Gottlieb

Research output: Contribution to journalArticle

Abstract

The authors examined the individual and relative roles of atrophy, comorbid medical illness, and cerebrovascular risk factors in the pathogenesis of late-life major depressive disorder (MDD). They used magnetic resonance imaging techniques to study 28 subjects with late-life MDD, 29 healthy control subjects, and 34 subjects with probable dementia of the Alzheimer type (DAT). Depressed subjects showed increases in cerebrospinal fluid volumes comparable to the DAT group but significantly different from control subjects. High-intensity signals, but not measures of atrophy correlated significantly with cerebrovascular risk factor scores. A logistic regression revealed that both brain atrophy and medical illness are associated with an increased risk of developing MDD. Data suggest that both atrophy and comorbid medical illness increase the likelihood of developing MDD in late life.

Original languageEnglish (US)
Pages (from-to)15-25
Number of pages11
JournalAmerican Journal of Geriatric Psychiatry
Volume5
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

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Major Depressive Disorder
Atrophy
Depression
Alzheimer Disease
Cerebrospinal Fluid
Healthy Volunteers
Logistic Models
Magnetic Resonance Imaging
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

Quantitative anatomic measures and comorbid medical illness in late- life major depression. / Kumar, A.; Miller, D.; Ewbank, D.; Yousem, David Mark; Newberg, A.; Samuels, S.; Cowell, P.; Gottlieb, G.

In: American Journal of Geriatric Psychiatry, Vol. 5, No. 1, 1997, p. 15-25.

Research output: Contribution to journalArticle

Kumar, A. ; Miller, D. ; Ewbank, D. ; Yousem, David Mark ; Newberg, A. ; Samuels, S. ; Cowell, P. ; Gottlieb, G. / Quantitative anatomic measures and comorbid medical illness in late- life major depression. In: American Journal of Geriatric Psychiatry. 1997 ; Vol. 5, No. 1. pp. 15-25.
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