TY - JOUR
T1 - Quantitative analysis of gray and white matter in Williams syndrome
AU - Faria, Andreia Vasconcellos
AU - Landau, Barbara
AU - O'Hearn, Kirsten M.
AU - Li, Xin
AU - Jiang, Hangyi
AU - Oishi, Kenichi
AU - Zhang, Jiangyang
AU - Mori, Susumu
PY - 2012/3/28
Y1 - 2012/3/28
N2 - Williams syndrome is a developmental disorder with a genetic basis, which results in an uneven cognitive profile with relatively strong language skills and severely impaired visuospatial abilities. To better understand the brain structure underlying this profile, we compared individuals with Williams syndrome with controls using multimodal neuroimaging data and new analytic methods (diffeomorphic mapping and atlas-based analysis). People with Williams syndrome had basal ganglia atrophy, while the fusiform, the medium temporal gyri, and the cerebellar cortex were relatively preserved. The right superior longitudinal fasciculus, the left frontooccipital fasciculus, the caudate, and the cingulum demonstrated increased fractional anisotropy, whereas the corticospinal tract revealed decreased values. These findings may be linked to the uneven cognitive profile evident in Williams syndrome.
AB - Williams syndrome is a developmental disorder with a genetic basis, which results in an uneven cognitive profile with relatively strong language skills and severely impaired visuospatial abilities. To better understand the brain structure underlying this profile, we compared individuals with Williams syndrome with controls using multimodal neuroimaging data and new analytic methods (diffeomorphic mapping and atlas-based analysis). People with Williams syndrome had basal ganglia atrophy, while the fusiform, the medium temporal gyri, and the cerebellar cortex were relatively preserved. The right superior longitudinal fasciculus, the left frontooccipital fasciculus, the caudate, and the cingulum demonstrated increased fractional anisotropy, whereas the corticospinal tract revealed decreased values. These findings may be linked to the uneven cognitive profile evident in Williams syndrome.
KW - Atlas-based analysis
KW - Diffusion tensor imaging
KW - MRI
KW - Williams syndrome
UR - http://www.scopus.com/inward/record.url?scp=84859317322&partnerID=8YFLogxK
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U2 - 10.1097/WNR.0b013e3283505b62
DO - 10.1097/WNR.0b013e3283505b62
M3 - Article
C2 - 22410548
AN - SCOPUS:84859317322
VL - 23
SP - 283
EP - 289
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 5
ER -