Abstract
We used immunocytochemical methods on sural nerve biopsies from 42 patients with peripheral neuropathy to identify mononuclear cells, determine whether lymphocytic infiltration occurs in a variety of neuropathies, and identify the subtypes of lymphocytes. Immunostained cells were present in 76% of nerve biopsies. CD3+ cells (T lymphocytes) were greatest in density (cells/mm2). In patients whose CD4: CD8 T cell ratio was measured also in blood and cerebrospinal fluid, the CD4:CD8 T cell ratio was similar in all three compartments. These findings suggest that T lymphocytes are frequently present in nerves obtained from patients with various types of neuropathies and raise questions about factorsthat attract T lymphocytes into nerve that may be important in pathogenesis.
Original language | English (US) |
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Pages (from-to) | 113-118 |
Number of pages | 6 |
Journal | Journal of Neuroimmunology |
Volume | 26 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1990 |
Keywords
- (HIV)
- (Human)
- Human immunodeficiency virus infection
- Neuropathy
- T cell
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology