Quantitative analysis of endoneurial T-cells in human sural nerve biopsies

David R. Cornblath, Diane E. Griffin, Danielle Welch, John W. Griffin, Justin C. McArthur

Research output: Contribution to journalArticlepeer-review

Abstract

We used immunocytochemical methods on sural nerve biopsies from 42 patients with peripheral neuropathy to identify mononuclear cells, determine whether lymphocytic infiltration occurs in a variety of neuropathies, and identify the subtypes of lymphocytes. Immunostained cells were present in 76% of nerve biopsies. CD3+ cells (T lymphocytes) were greatest in density (cells/mm2). In patients whose CD4: CD8 T cell ratio was measured also in blood and cerebrospinal fluid, the CD4:CD8 T cell ratio was similar in all three compartments. These findings suggest that T lymphocytes are frequently present in nerves obtained from patients with various types of neuropathies and raise questions about factorsthat attract T lymphocytes into nerve that may be important in pathogenesis.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalJournal of Neuroimmunology
Volume26
Issue number2
DOIs
StatePublished - Feb 1990

Keywords

  • (HIV)
  • (Human)
  • Human immunodeficiency virus infection
  • Neuropathy
  • T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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