Quantitative accuracy considerations in dynamic state-of-the-art PET imaging (when average counts-per-LOR are (much) less than unity)

Arman Rahmim, Ju Chieh Cheng, Stefan Blinder, Marie Laure Camborde, Vesna Sossi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

State-of-the-art high resolution PET is now more than ever in need of scrutiny into the nature and limitations of the imaging modality itself as well as image reconstruction techniques. Particularly, we have discussed and addressed the following two considerations in the context of dynamic PET imaging: (i) The typical average numbers of counts-per-LOR are now (much) less than unity.; (ii) The wide range of statistics (due to physical/biological decay of the activity) coupled with the aforementioned low count-rates-per-LOR further challenge the quantitative accuracy of dynamic reconstructions. In this context, we have argued theoretically and demonstrated experimentally, that the sinogram non-negativity constraint (when using the delayed coincidence and/or scatter subtraction techniques) will result in considerable overestimation biases. Two alternate schemes have been considered, and have been shown to remove the aforementioned bias. We have also investigated applicabilities of ordinary and convergent subsetized image reconstruction methods.

Original languageEnglish (US)
Title of host publication2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Pages2253-2255
Number of pages3
DOIs
StatePublished - Dec 1 2005
EventNuclear Science Symposium Conference Record, 2005 IEEE - , Puerto Rico
Duration: Oct 23 2005Oct 29 2005

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume4
ISSN (Print)1095-7863

Other

OtherNuclear Science Symposium Conference Record, 2005 IEEE
CountryPuerto Rico
Period10/23/0510/29/05

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Rahmim, A., Cheng, J. C., Blinder, S., Camborde, M. L., & Sossi, V. (2005). Quantitative accuracy considerations in dynamic state-of-the-art PET imaging (when average counts-per-LOR are (much) less than unity). In 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference (pp. 2253-2255). [1596783] (IEEE Nuclear Science Symposium Conference Record; Vol. 4). https://doi.org/10.1109/NSSMIC.2005.1596783