Quantitation of regional cerebral blood flow increases in prefrontal cortex during a working memory task: A steady-state arterial spin-tagging study

Frank Q. Ye, Anne M. Smith, Venkata S. Mattay, Urs E. Ruttimann, Joseph A. Frank, Daniel R. Weinberger, Alan C. McLaughlin

Research output: Contribution to journalArticle

Abstract

Steady-state arterial spin-tagging MRI approaches were used to quantitate regional cerebral blood flow increases in prefrontal cortex during a working memory ('two-back') task in six normal subjects. Statistically significant increases in cerebral blood flow in prefrontal cortex were observed in all six subjects: the average increase in cerebral blood flow in activated prefrontal cortex regions was 22 ± 5 cc/100 g/min (23 ± 7%). The results demonstrate that spin-tagging approaches can be used to follow focal activation in prefrontal cortex during cognitive tasks.

Original languageEnglish (US)
Pages (from-to)44-49
Number of pages6
JournalNeuroImage
Volume8
Issue number1
DOIs
StatePublished - Jul 1998
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this