Quantitation of regional cerebral blood flow increases in prefrontal cortex during a working memory task: A steady-state arterial spin-tagging study

Frank Q. Ye; Anne M. Smith; Venkata S. Mattay; Urs E. Ruttimann; Joseph A. Frank; Daniel R. Weinberger; Alan C. McLaughlin

doi:10.1006/nimg.1998.0342

Quantitation of regional cerebral blood flow increases in prefrontal cortex during a working memory task: A steady-state arterial spin-tagging study

Frank Q. Ye, Anne M. Smith, Venkata S. Mattay, Urs E. Ruttimann, Joseph A. Frank, Daniel R. Weinberger, Alan C. McLaughlin

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Steady-state arterial spin-tagging MRI approaches were used to quantitate regional cerebral blood flow increases in prefrontal cortex during a working memory ('two-back') task in six normal subjects. Statistically significant increases in cerebral blood flow in prefrontal cortex were observed in all six subjects: the average increase in cerebral blood flow in activated prefrontal cortex regions was 22 ± 5 cc/100 g/min (23 ± 7%). The results demonstrate that spin-tagging approaches can be used to follow focal activation in prefrontal cortex during cognitive tasks.

Original language	English (US)
Pages (from-to)	44-49
Number of pages	6
Journal	NeuroImage
Volume	8
Issue number	1
DOIs	https://doi.org/10.1006/nimg.1998.0342
State	Published - Jul 1998
Externally published	Yes

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1006/nimg.1998.0342

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abstract = "Steady-state arterial spin-tagging MRI approaches were used to quantitate regional cerebral blood flow increases in prefrontal cortex during a working memory ('two-back') task in six normal subjects. Statistically significant increases in cerebral blood flow in prefrontal cortex were observed in all six subjects: the average increase in cerebral blood flow in activated prefrontal cortex regions was 22 ± 5 cc/100 g/min (23 ± 7%). The results demonstrate that spin-tagging approaches can be used to follow focal activation in prefrontal cortex during cognitive tasks.",

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AU - Frank, Joseph A.

AU - Weinberger, Daniel R.

AU - McLaughlin, Alan C.

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Quantitation of regional cerebral blood flow increases in prefrontal cortex during a working memory task: A steady-state arterial spin-tagging study

Abstract

ASJC Scopus subject areas

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