Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference

Brian J. Soher, Ralph E. Hurd, Napapon Sailasuta, Peter B. Barker

Research output: Contribution to journalArticle

Abstract

Data from a previously published, multi-site trial (P. G. Webb, N. Sailasuta, S. J. Kohler, T. Raidy, R. A. Moats, R. E. Hurd, Automated single- voxel proton MRS: technical development and multisite verification. Magn. Reson. Med. 31, 365-373 (1994)) of a fully automatic, single-voxel, proton spectroscopy package (PROBE/SV, GE Medical Systems) was re-analyzed in terms of absolute metabolite concentrations using the cerebral water signal as an internal reference. In 100 spectra from parietal white matter in normal volunteers ranging in age from 22 to 34 years at eight sites, overall concentrations of choline (Cho), creatine (Cr), and N-acetyl-aspartate (NAA) resonances were found to be 2.00 ± 0.50, 8.43 ± 1.26, and 12.55 ± 1.76 umol/g wet weight, respectively. These values are in good general agreement with previously published values from quantitative, single-voxel studies. Metabolite concentrations for NAA, Cr, and Cho across all sites had standard deviations of 14.4%, 14.9%, and 25.1%, respectively. Quantitation of PROBE data sets is routinely possible by using the cerebral water signal as an internal reference.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalMagnetic resonance in medicine
Volume36
Issue number3
DOIs
StatePublished - Sep 1996

Keywords

  • proton MR spectroscopy
  • quantitation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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