Quantifying the Interaction and Contribution of Multiple Datasets in Fusion: Application to the Detection of Schizophrenia

Yuri Levin-Schwartz, Vince D. Calhoun, Tulay Adali

Research output: Contribution to journalArticlepeer-review

Abstract

The extraction of information from multiple sets of data is a problem inherent to many disciplines. This is possible by either analyzing the data sets jointly as in data fusion or separately and then combining as in data integration. However, selecting the optimal method to combine and analyze multiset data is an ever-present challenge. The primary reason for this is the difficulty in determining the optimal contribution of each data set to an analysis as well as the amount of potentially exploitable complementary information among data sets. In this paper, we propose a novel classification rate-based technique to unambiguously quantify the contribution of each data set to a fusion result as well as facilitate direct comparisons of fusion methods on real data and apply a new method, independent vector analysis (IVA), to multiset fusion. This classification rate-based technique is used on functional magnetic resonance imaging data collected from 121 patients with schizophrenia and 150 healthy controls during the performance of three tasks. Through this application, we find that though optimal performance is achieved by exploiting all tasks, each task does not contribute equally to the result and this framework enables effective quantification of the value added by each task. Our results also demonstrate that data fusion methods are more powerful than data integration methods, with the former achieving a classification rate of 73.5 % and the latter achieving one of 70.9 %, a difference which we show is significant when all three tasks are analyzed together. Finally, we show that IVA, due to its flexibility, has equivalent or superior performance compared with the popular data fusion method, joint independent component analysis.

Original languageEnglish (US)
Article number7872466
Pages (from-to)1385-1395
Number of pages11
JournalIEEE transactions on medical imaging
Volume36
Issue number7
DOIs
StatePublished - Jul 2017

Keywords

  • Functional magnetic resonance imaging (fMRI)
  • ICA
  • IVA
  • data fusion
  • schizophrenia

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering

Fingerprint

Dive into the research topics of 'Quantifying the Interaction and Contribution of Multiple Datasets in Fusion: Application to the Detection of Schizophrenia'. Together they form a unique fingerprint.

Cite this