TY - JOUR
T1 - Quantifying mechanical heterogeneity in canine acute lung injury
T2 - Impact of mean airway pressure
AU - Kaczka, David W.
AU - Hager, David N.
AU - Hawley, Monica L.
AU - Simon, Brett A.
N1 - Funding Information:
Received from the Departments of Anesthesiology and Critical Care Medicine and Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland. Submitted for publication December 20, 2004. Accepted for publication April 6, 2005. Supported by a Research Starter Grant from the Foundation for Anesthesia Education and Research, Rochester, Minnesota, and grant No. R01 HL-58504 from the National Institutes of Health, Washington, D.C. Dr. Kaczka is listed as primary inventor on a provisional U.S. Patent for the pneumatic oscillator described in the Materials and Methods section of the manuscript, which is owned by the Trustees of Boston, University, Boston, Massachusetts. Currently, there are no licensing agreements between Dr. Kaczka and Boston University or any other third party regarding this technology.
PY - 2005/8
Y1 - 2005/8
N2 - Background: The heterogeneous pattern of acute lung injury (ALI) predisposes patients to ventilator-associated lung injury. Currently, there is no simple technique that can reliably quantify lung heterogeneity during the dynamic conditions of mechanical ventilation. Such a technique may be of use in optimizing mechanical ventilatory parameters such as rate, tidal volume, or positive end-expiratory pressure. Methods: To determine the impact of heterogeneity on respiratory mechanics, the authors measured respiratory impedance (Zrs), expressed as respiratory resistance (Rrs) and elastance (Ers), in 11 anesthetized dogs from 0.078 to 8.9 Hz using broad-band pressure and flow excitations under baseline conditions and after ALI produced by infusion of 0.08 ml/kg oleic acid into the right atrium. Data were obtained at mean airway pressures (P̄ao) of 5, 10, 15, and 20 cm H2O. The Zrs spectra were fit by various models of the respiratory system incorporating different distributions of parallel viscoelastic tissue properties. Results: Under baseline conditions, both R rs and Ers exhibited dependence on oscillation frequency, reflecting viscoelastic behavior. The Ers demonstrated significant dependence on P̄ao. After ALI, both the level and frequency dependence of Rrs and Ers increased, as well as the apparent heterogeneity of tissue properties. Both Rrs and E rs as well as heterogeneity decreased with increasing P̄ao, approaching baseline levels at the highest levels of P̄ao. Conclusions: These data demonstrate that Zrs can provide specific information regarding the mechanical heterogeneity of injured lungs at different levels of P̄ao. Moderate increases in P̄ao seem to be beneficial in ALI by reducing heterogeneity and recruiting lung units. These noninvasive measurements of lung heterogeneity may ultimately allow for the development of better ventilation protocols that optimize regional lung mechanics in patients with ALI.
AB - Background: The heterogeneous pattern of acute lung injury (ALI) predisposes patients to ventilator-associated lung injury. Currently, there is no simple technique that can reliably quantify lung heterogeneity during the dynamic conditions of mechanical ventilation. Such a technique may be of use in optimizing mechanical ventilatory parameters such as rate, tidal volume, or positive end-expiratory pressure. Methods: To determine the impact of heterogeneity on respiratory mechanics, the authors measured respiratory impedance (Zrs), expressed as respiratory resistance (Rrs) and elastance (Ers), in 11 anesthetized dogs from 0.078 to 8.9 Hz using broad-band pressure and flow excitations under baseline conditions and after ALI produced by infusion of 0.08 ml/kg oleic acid into the right atrium. Data were obtained at mean airway pressures (P̄ao) of 5, 10, 15, and 20 cm H2O. The Zrs spectra were fit by various models of the respiratory system incorporating different distributions of parallel viscoelastic tissue properties. Results: Under baseline conditions, both R rs and Ers exhibited dependence on oscillation frequency, reflecting viscoelastic behavior. The Ers demonstrated significant dependence on P̄ao. After ALI, both the level and frequency dependence of Rrs and Ers increased, as well as the apparent heterogeneity of tissue properties. Both Rrs and E rs as well as heterogeneity decreased with increasing P̄ao, approaching baseline levels at the highest levels of P̄ao. Conclusions: These data demonstrate that Zrs can provide specific information regarding the mechanical heterogeneity of injured lungs at different levels of P̄ao. Moderate increases in P̄ao seem to be beneficial in ALI by reducing heterogeneity and recruiting lung units. These noninvasive measurements of lung heterogeneity may ultimately allow for the development of better ventilation protocols that optimize regional lung mechanics in patients with ALI.
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U2 - 10.1097/00000542-200508000-00014
DO - 10.1097/00000542-200508000-00014
M3 - Article
C2 - 16052113
AN - SCOPUS:23044465762
SN - 0003-3022
VL - 103
SP - 306
EP - 317
JO - Anesthesiology
JF - Anesthesiology
IS - 2
ER -