TY - JOUR
T1 - Quantifying left atrial structure and function using single-plane tissue-tracking cardiac magnetic resonance
AU - Tao, Susumu
AU - Ciuffo, Luisa A.
AU - Lima, Joao A.C.
AU - Wu, Katherine C.
AU - Ashikaga, Hiroshi
N1 - Funding Information:
This study was supported by Japanese Heart Rhythm Society Medtronic fellowship 2015-2016 (to S.T.) and National Institutes of Health grant R01HL103812 (to K.C·W). The authors thank Tarek Zghaib for collecting data and Hassan Elahi for advice to data analysis.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2017/10
Y1 - 2017/10
N2 - Purpose Left atrial (LA) structure and function are important markers of adverse cardiovascular outcomes. Tissue-tracking cardiovascular magnetic resonance (CMR) accurately quantifies LA volume, strain, and strain rate based on biplane long-axis imaging. We aimed to assess the accuracy of the LA indices quantification from single-plane tissue-tracking CMR. Methods We included 388 subjects (mean age 57±13, male 70%) whose cine CMR images in sinus rhythm were available in both four-chamber and two-chamber views: 162 patients from the Prospective Observational Study of Implantable Cardioverter-Defibrillators (PROSE-ICD) Study, 208 patients from atrial fibrillation cohort, and 18 healthy volunteers. The group was divided into the training set (n = 291) and the test set (n = 97). In the training set, we compared the LA indices derived from biplane imaging and single-plane imaging (a four-chamber view), and developed regression equations. In the test set, we used the regression equations to estimate the LA indices from the single-plane imaging, and quantified the accuracy of the estimation against the LA indices from the biplane. Results In the training set, all the LA indices from the single-plane imaging tended to be systematically underestimated compared with those from the biplane imaging, however, the correlation coefficient was high (r2 = 0.73–0.90, p < 0.001). In the test set, LA volumetric indices showed excellent reproducibility (intra-class correlation coefficient (ICC): 0.91–0.92) with relatively low variability (16.3–22.3%); For LA strain and strain rate indices, reproducibility was excellent (ICC: 0.81–0.93), however, the variability was slightly higher than that of volumetric indices (21.7–25.4%). Conclusions LA volumetric indices measured from single-plane tissue-tracking CMR are highly accurate and reproducible with reference to those derived from the standard biplane imaging. The reproducibility of LA strain and strain rate indices from single-plane tissue-tracking CMR is excellent but the variability is higher than that of the volumetric indices.
AB - Purpose Left atrial (LA) structure and function are important markers of adverse cardiovascular outcomes. Tissue-tracking cardiovascular magnetic resonance (CMR) accurately quantifies LA volume, strain, and strain rate based on biplane long-axis imaging. We aimed to assess the accuracy of the LA indices quantification from single-plane tissue-tracking CMR. Methods We included 388 subjects (mean age 57±13, male 70%) whose cine CMR images in sinus rhythm were available in both four-chamber and two-chamber views: 162 patients from the Prospective Observational Study of Implantable Cardioverter-Defibrillators (PROSE-ICD) Study, 208 patients from atrial fibrillation cohort, and 18 healthy volunteers. The group was divided into the training set (n = 291) and the test set (n = 97). In the training set, we compared the LA indices derived from biplane imaging and single-plane imaging (a four-chamber view), and developed regression equations. In the test set, we used the regression equations to estimate the LA indices from the single-plane imaging, and quantified the accuracy of the estimation against the LA indices from the biplane. Results In the training set, all the LA indices from the single-plane imaging tended to be systematically underestimated compared with those from the biplane imaging, however, the correlation coefficient was high (r2 = 0.73–0.90, p < 0.001). In the test set, LA volumetric indices showed excellent reproducibility (intra-class correlation coefficient (ICC): 0.91–0.92) with relatively low variability (16.3–22.3%); For LA strain and strain rate indices, reproducibility was excellent (ICC: 0.81–0.93), however, the variability was slightly higher than that of volumetric indices (21.7–25.4%). Conclusions LA volumetric indices measured from single-plane tissue-tracking CMR are highly accurate and reproducible with reference to those derived from the standard biplane imaging. The reproducibility of LA strain and strain rate indices from single-plane tissue-tracking CMR is excellent but the variability is higher than that of the volumetric indices.
KW - Cardiovascular magnetic resonance
KW - Left atrium
KW - Structure and function
KW - Tissue tracking
UR - http://www.scopus.com/inward/record.url?scp=85021131325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021131325&partnerID=8YFLogxK
U2 - 10.1016/j.mri.2017.06.003
DO - 10.1016/j.mri.2017.06.003
M3 - Article
C2 - 28642098
AN - SCOPUS:85021131325
SN - 0730-725X
VL - 42
SP - 130
EP - 138
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
ER -