Abstract
Focal disruptions in axonal microtubules are a common consequence of Traumatic Brain Injuries (TBIs), and the ability to quantify these disruptions is essential to evaluating in vitro injury models and therapies. Here, we develop and implement an algorithm to demonstrate the ability to quantify focal disruptions in the microtubules of cultured neurons. The algorithm is implemented using a combination of ImageJ for pre-processing and Matlab for axon analysis and tubulin breakdown identification.
| Original language | English (US) |
|---|---|
| Title of host publication | 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| ISBN (Electronic) | 9781479983605 |
| DOIs | |
| State | Published - Jun 2 2015 |
| Externally published | Yes |
| Event | 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States Duration: Apr 17 2015 → Apr 19 2015 |
Publication series
| Name | 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 |
|---|
Other
| Other | 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 |
|---|---|
| Country | United States |
| City | Troy |
| Period | 4/17/15 → 4/19/15 |
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ASJC Scopus subject areas
- Biotechnology
- Cancer Research
- Cell Biology
- Molecular Medicine
- Biomedical Engineering
- Control and Systems Engineering
Cite this
Quantifying focal disruptions in axonal microtubules. / Dastgheyb, Raha; Barbee, K. A.; Gallo, G.
2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7117155 (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Quantifying focal disruptions in axonal microtubules
AU - Dastgheyb, Raha
AU - Barbee, K. A.
AU - Gallo, G.
PY - 2015/6/2
Y1 - 2015/6/2
N2 - Focal disruptions in axonal microtubules are a common consequence of Traumatic Brain Injuries (TBIs), and the ability to quantify these disruptions is essential to evaluating in vitro injury models and therapies. Here, we develop and implement an algorithm to demonstrate the ability to quantify focal disruptions in the microtubules of cultured neurons. The algorithm is implemented using a combination of ImageJ for pre-processing and Matlab for axon analysis and tubulin breakdown identification.
AB - Focal disruptions in axonal microtubules are a common consequence of Traumatic Brain Injuries (TBIs), and the ability to quantify these disruptions is essential to evaluating in vitro injury models and therapies. Here, we develop and implement an algorithm to demonstrate the ability to quantify focal disruptions in the microtubules of cultured neurons. The algorithm is implemented using a combination of ImageJ for pre-processing and Matlab for axon analysis and tubulin breakdown identification.
UR - http://www.scopus.com/inward/record.url?scp=84941028978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941028978&partnerID=8YFLogxK
U2 - 10.1109/NEBEC.2015.7117155
DO - 10.1109/NEBEC.2015.7117155
M3 - Conference contribution
AN - SCOPUS:84941028978
T3 - 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
BT - 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
PB - Institute of Electrical and Electronics Engineers Inc.
ER -