Quantifying fixation in patients with Stargardt disease

Jens Reinhard, André Messias, Klaus Dietz, Manfred MacKeben, Raimund Lakmann, Hendrik P.N. Scholl, Eckart Apfelstedt-Sylla, Bernhard H.F. Weber, Mathias W. Seeliger, Eberhart Zrenner, Susanne Trauzettel-Klosinski

Research output: Contribution to journalArticle


Fixational eye movements in 60 eyes of 30 patients with ABCA4-associated Stargardt disease were recorded by a Scanning Laser Ophthalmoscope (SLO). The results were quantified by two new fixation quality measures expressing the eccentricity of the preferred retinal locus (PRL) non-parametrically, and fixation stability by a dynamic index. 46 eyes (77%) fixated eccentrically; in 32 eyes (70% of the eccentrically fixating eyes) the PRL was located above the central retinal lesion. PRL eccentricity correlated positively with logMAR visual acuity (r = .72; p < .0001) and negatively with fixation stability (r = -.58; p < .0001). Multiple PRL were found only in three eyes.

Original languageEnglish (US)
Pages (from-to)2076-2085
Number of pages10
JournalVision Research
Issue number15
StatePublished - Jul 1 2007



  • Fixation stability
  • Maculopathy
  • Preferred retinal locus (PRL)
  • Scanning Laser Ophthalmoscope (SLO)
  • Stargardt disease

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Reinhard, J., Messias, A., Dietz, K., MacKeben, M., Lakmann, R., Scholl, H. P. N., Apfelstedt-Sylla, E., Weber, B. H. F., Seeliger, M. W., Zrenner, E., & Trauzettel-Klosinski, S. (2007). Quantifying fixation in patients with Stargardt disease. Vision Research, 47(15), 2076-2085. https://doi.org/10.1016/j.visres.2007.04.012