TY - JOUR
T1 - Quantifying fixation in patients with Stargardt disease
AU - Reinhard, Jens
AU - Messias, André
AU - Dietz, Klaus
AU - MacKeben, Manfred
AU - Lakmann, Raimund
AU - Scholl, Hendrik P.N.
AU - Apfelstedt-Sylla, Eckart
AU - Weber, Bernhard H.F.
AU - Seeliger, Mathias W.
AU - Zrenner, Eberhart
AU - Trauzettel-Klosinski, Susanne
N1 - Funding Information:
This study was supported by the Ministry of Science, Research and Arts, Baden-Württemberg (Germany), the German Research Council (DFG Zr 1/14-1, Zr 1/14-2 and Zr 1/17-1), the European Integrated Project “EVI-GENORET” (LSHG-CT-2005-512036) and the ProRetina Society (Germany). The authors are indebted to two anonymous reviewers, whose comments substantially improved the final version of the manuscript.
PY - 2007/7
Y1 - 2007/7
N2 - Fixational eye movements in 60 eyes of 30 patients with ABCA4-associated Stargardt disease were recorded by a Scanning Laser Ophthalmoscope (SLO). The results were quantified by two new fixation quality measures expressing the eccentricity of the preferred retinal locus (PRL) non-parametrically, and fixation stability by a dynamic index. 46 eyes (77%) fixated eccentrically; in 32 eyes (70% of the eccentrically fixating eyes) the PRL was located above the central retinal lesion. PRL eccentricity correlated positively with logMAR visual acuity (r = .72; p < .0001) and negatively with fixation stability (r = -.58; p < .0001). Multiple PRL were found only in three eyes.
AB - Fixational eye movements in 60 eyes of 30 patients with ABCA4-associated Stargardt disease were recorded by a Scanning Laser Ophthalmoscope (SLO). The results were quantified by two new fixation quality measures expressing the eccentricity of the preferred retinal locus (PRL) non-parametrically, and fixation stability by a dynamic index. 46 eyes (77%) fixated eccentrically; in 32 eyes (70% of the eccentrically fixating eyes) the PRL was located above the central retinal lesion. PRL eccentricity correlated positively with logMAR visual acuity (r = .72; p < .0001) and negatively with fixation stability (r = -.58; p < .0001). Multiple PRL were found only in three eyes.
KW - Fixation stability
KW - Maculopathy
KW - Preferred retinal locus (PRL)
KW - Scanning Laser Ophthalmoscope (SLO)
KW - Stargardt disease
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U2 - 10.1016/j.visres.2007.04.012
DO - 10.1016/j.visres.2007.04.012
M3 - Article
C2 - 17562343
AN - SCOPUS:34250201469
SN - 0042-6989
VL - 47
SP - 2076
EP - 2085
JO - Vision Research
JF - Vision Research
IS - 15
ER -