TY - JOUR
T1 - Quantifying fibrosis in venous disease
T2 - mechanical properties of lipodermatosclerotic and healthy tissue.
AU - Geyer, Mary Jo
AU - Brienza, David M.
AU - Chib, Vikram
AU - Wang, Jue
PY - 2004/4
Y1 - 2004/4
N2 - OBJECTIVES: To quantify the mechanical properties of medioposterior bulk calf tissue in patients with lipodermatosclerotic venous-insufficient tissue and individuals with apparently healthy tissue using a novel ultrasound indentometry method, and to identify parameters with the potential for quantifying fibrosis in subsequent studies. DESIGN: 2-group, quasi-experimental design SETTING: Soft Tissue Mechanics Laboratory, University of Pittsburgh, Pittsburgh, PA PARTICIPANTS: 9 healthy and 9 venous-insufficient individuals aged 35 to 85 years INTERVENTIONS: Ultrasound indentometry and computed tomography (CT) of calf tissue MAIN OUTCOME MEASURES: Between group differences and associations among quasi-linear viscoelastic (QLV) tissue parameters and CT descriptors MAIN RESULTS: Established the accuracy, validity, and reliability of the QLV model and ultrasound indentometry method. Demonstrated a range of significant differences between the groups (P <.020 to P <.004) for selected QLV parameters. Also found significant correlations between CT measures of fibrosis and dermal thickness and QLV elastic measures (P <.034 to P <.005). CONCLUSION: Attempts to quantify fibrosis in lipodermatosclerosis have included histologic exams, palpation/pitting, durometer readings, and imaging techniques, but these efforts have failed to produce a clinically practical, noninvasive method. A novel ultrasound indentometry method was used to acquire in vivo data from which tissue parameters were derived. These data support the further development of ultrasound indentometry as a method to quantify fibrosis in venous disease.
AB - OBJECTIVES: To quantify the mechanical properties of medioposterior bulk calf tissue in patients with lipodermatosclerotic venous-insufficient tissue and individuals with apparently healthy tissue using a novel ultrasound indentometry method, and to identify parameters with the potential for quantifying fibrosis in subsequent studies. DESIGN: 2-group, quasi-experimental design SETTING: Soft Tissue Mechanics Laboratory, University of Pittsburgh, Pittsburgh, PA PARTICIPANTS: 9 healthy and 9 venous-insufficient individuals aged 35 to 85 years INTERVENTIONS: Ultrasound indentometry and computed tomography (CT) of calf tissue MAIN OUTCOME MEASURES: Between group differences and associations among quasi-linear viscoelastic (QLV) tissue parameters and CT descriptors MAIN RESULTS: Established the accuracy, validity, and reliability of the QLV model and ultrasound indentometry method. Demonstrated a range of significant differences between the groups (P <.020 to P <.004) for selected QLV parameters. Also found significant correlations between CT measures of fibrosis and dermal thickness and QLV elastic measures (P <.034 to P <.005). CONCLUSION: Attempts to quantify fibrosis in lipodermatosclerosis have included histologic exams, palpation/pitting, durometer readings, and imaging techniques, but these efforts have failed to produce a clinically practical, noninvasive method. A novel ultrasound indentometry method was used to acquire in vivo data from which tissue parameters were derived. These data support the further development of ultrasound indentometry as a method to quantify fibrosis in venous disease.
UR - http://www.scopus.com/inward/record.url?scp=3142518134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3142518134&partnerID=8YFLogxK
U2 - 10.1097/00129334-200404000-00014
DO - 10.1097/00129334-200404000-00014
M3 - Article
C2 - 2004107775
AN - SCOPUS:3142518134
VL - 17
SP - 131
EP - 142
JO - Advances in Skin and Wound Care
JF - Advances in Skin and Wound Care
SN - 1527-7941
IS - 3
ER -