Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2-based oxygenation calibrations

Wenbo Li; Xiang Xu; Peiying Liu; John J. Strouse; James F. Casella; Hanzhang Lu; Peter C.M. van Zijl; Qin Qin

doi:10.1002/mrm.27972

Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T₂-based oxygenation calibrations

Wenbo Li, Xiang Xu, Peiying Liu, John J. Strouse, James F. Casella, Hanzhang Lu, Peter C.M. van Zijl, Qin Qin

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Purpose: To evaluate different T₂-oxygenation calibrations for estimating venous oxygenation in people with sickle cell anemia (SCA). Methods: Blood T₂ values were measured at 3 T in the internal jugular veins of 12 healthy volunteers and 11 SCA participants with no history of stroke, recent transfusion, or renal impairment. T₂-oxygenation relationships of both sickled and normal blood samples were calibrated individually and compared with values generated from published models. After converting venous T₂ values to venous oxygenation, whole-brain oxygen extraction fraction and cerebral metabolic rate of oxygen were calculated. Results: Sickle blood samples' oxygenation values calculated from our individual calibrations agreed well with measurements using a blood analyzer, whereas previous T₂ calibrations based on normal blood samples showed 13%-19% underestimation. Meanwhile, oxygenation values calculated from previous grouped T₂ calibration for sickle blood agreed well with experimental measurement on averaged values, but showed up to 20% variation for several individual samples. Using individual T₂ calibrations, the whole-brain oxygen extraction fraction and cerebral metabolic rate of oxygen of SCA participants were 0.38 ± 0.08 and 172 ± 42 µmol/min/100 g, respectively, which were comparable to those values measured on healthy volunteers. Conclusion: Our results confirm that sickle blood T₂ values not only depend on the hematocrit and oxygenation values, but also on other hematological factors. The individual T₂ calibrations minimized the effect of heterogeneity of sickle blood between different SCA populations and improved the accuracy of T₂-based oximetry. The measured oxygen extraction fraction and cerebral metabolic rate of oxygen of this group of SCA participants were found to not differ significantly from those of healthy individuals.

Original language	English (US)
Pages (from-to)	1066-1080
Number of pages	15
Journal	Magnetic resonance in medicine
Volume	83
Issue number	3
DOIs	https://doi.org/10.1002/mrm.27972
State	Published - Mar 1 2020

Keywords

CMRO
HbS
OEF
T oximetry
blood T
sickle cell disease

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1002/mrm.27972

Cite this

Li, W., Xu, X., Liu, P., Strouse, J. J., Casella, J. F., Lu, H., van Zijl, P. C. M., & Qin, Q. (2020). Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T₂-based oxygenation calibrations. Magnetic resonance in medicine, 83(3), 1066-1080. https://doi.org/10.1002/mrm.27972

Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T₂-based oxygenation calibrations. / Li, Wenbo; Xu, Xiang; Liu, Peiying et al.
In: Magnetic resonance in medicine, Vol. 83, No. 3, 01.03.2020, p. 1066-1080.

Research output: Contribution to journal › Article › peer-review

Li, W, Xu, X, Liu, P, Strouse, JJ, Casella, JF , Lu, H , van Zijl, PCM & Qin, Q 2020, 'Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T₂-based oxygenation calibrations', Magnetic resonance in medicine, vol. 83, no. 3, pp. 1066-1080. https://doi.org/10.1002/mrm.27972

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title = "Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2-based oxygenation calibrations",

abstract = "Purpose: To evaluate different T2-oxygenation calibrations for estimating venous oxygenation in people with sickle cell anemia (SCA). Methods: Blood T2 values were measured at 3 T in the internal jugular veins of 12 healthy volunteers and 11 SCA participants with no history of stroke, recent transfusion, or renal impairment. T2-oxygenation relationships of both sickled and normal blood samples were calibrated individually and compared with values generated from published models. After converting venous T2 values to venous oxygenation, whole-brain oxygen extraction fraction and cerebral metabolic rate of oxygen were calculated. Results: Sickle blood samples' oxygenation values calculated from our individual calibrations agreed well with measurements using a blood analyzer, whereas previous T2 calibrations based on normal blood samples showed 13%-19% underestimation. Meanwhile, oxygenation values calculated from previous grouped T2 calibration for sickle blood agreed well with experimental measurement on averaged values, but showed up to 20% variation for several individual samples. Using individual T2 calibrations, the whole-brain oxygen extraction fraction and cerebral metabolic rate of oxygen of SCA participants were 0.38 ± 0.08 and 172 ± 42 µmol/min/100 g, respectively, which were comparable to those values measured on healthy volunteers. Conclusion: Our results confirm that sickle blood T2 values not only depend on the hematocrit and oxygenation values, but also on other hematological factors. The individual T2 calibrations minimized the effect of heterogeneity of sickle blood between different SCA populations and improved the accuracy of T2-based oximetry. The measured oxygen extraction fraction and cerebral metabolic rate of oxygen of this group of SCA participants were found to not differ significantly from those of healthy individuals.",

keywords = "CMRO, HbS, OEF, T oximetry, blood T, sickle cell disease",

author = "Wenbo Li and Xiang Xu and Peiying Liu and Strouse, {John J.} and Casella, {James F.} and Hanzhang Lu and {van Zijl}, {Peter C.M.} and Qin Qin",

note = "Publisher Copyright: {\textcopyright} 2019 International Society for Magnetic Resonance in Medicine",

year = "2020",

month = mar,

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doi = "10.1002/mrm.27972",

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T1 - Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2-based oxygenation calibrations

AU - Li, Wenbo

AU - Xu, Xiang

AU - Liu, Peiying

AU - Strouse, John J.

AU - Casella, James F.

AU - Lu, Hanzhang

AU - van Zijl, Peter C.M.

AU - Qin, Qin

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Purpose: To evaluate different T2-oxygenation calibrations for estimating venous oxygenation in people with sickle cell anemia (SCA). Methods: Blood T2 values were measured at 3 T in the internal jugular veins of 12 healthy volunteers and 11 SCA participants with no history of stroke, recent transfusion, or renal impairment. T2-oxygenation relationships of both sickled and normal blood samples were calibrated individually and compared with values generated from published models. After converting venous T2 values to venous oxygenation, whole-brain oxygen extraction fraction and cerebral metabolic rate of oxygen were calculated. Results: Sickle blood samples' oxygenation values calculated from our individual calibrations agreed well with measurements using a blood analyzer, whereas previous T2 calibrations based on normal blood samples showed 13%-19% underestimation. Meanwhile, oxygenation values calculated from previous grouped T2 calibration for sickle blood agreed well with experimental measurement on averaged values, but showed up to 20% variation for several individual samples. Using individual T2 calibrations, the whole-brain oxygen extraction fraction and cerebral metabolic rate of oxygen of SCA participants were 0.38 ± 0.08 and 172 ± 42 µmol/min/100 g, respectively, which were comparable to those values measured on healthy volunteers. Conclusion: Our results confirm that sickle blood T2 values not only depend on the hematocrit and oxygenation values, but also on other hematological factors. The individual T2 calibrations minimized the effect of heterogeneity of sickle blood between different SCA populations and improved the accuracy of T2-based oximetry. The measured oxygen extraction fraction and cerebral metabolic rate of oxygen of this group of SCA participants were found to not differ significantly from those of healthy individuals.

AB - Purpose: To evaluate different T2-oxygenation calibrations for estimating venous oxygenation in people with sickle cell anemia (SCA). Methods: Blood T2 values were measured at 3 T in the internal jugular veins of 12 healthy volunteers and 11 SCA participants with no history of stroke, recent transfusion, or renal impairment. T2-oxygenation relationships of both sickled and normal blood samples were calibrated individually and compared with values generated from published models. After converting venous T2 values to venous oxygenation, whole-brain oxygen extraction fraction and cerebral metabolic rate of oxygen were calculated. Results: Sickle blood samples' oxygenation values calculated from our individual calibrations agreed well with measurements using a blood analyzer, whereas previous T2 calibrations based on normal blood samples showed 13%-19% underestimation. Meanwhile, oxygenation values calculated from previous grouped T2 calibration for sickle blood agreed well with experimental measurement on averaged values, but showed up to 20% variation for several individual samples. Using individual T2 calibrations, the whole-brain oxygen extraction fraction and cerebral metabolic rate of oxygen of SCA participants were 0.38 ± 0.08 and 172 ± 42 µmol/min/100 g, respectively, which were comparable to those values measured on healthy volunteers. Conclusion: Our results confirm that sickle blood T2 values not only depend on the hematocrit and oxygenation values, but also on other hematological factors. The individual T2 calibrations minimized the effect of heterogeneity of sickle blood between different SCA populations and improved the accuracy of T2-based oximetry. The measured oxygen extraction fraction and cerebral metabolic rate of oxygen of this group of SCA participants were found to not differ significantly from those of healthy individuals.

KW - CMRO

KW - HbS

KW - OEF

KW - T oximetry

KW - blood T

KW - sickle cell disease

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