Quantification of traumatic meningeal injury using dynamic contrast enhanced (DCE) fluid-attenuated inversion recovery (FLAIR) imaging

Marcelo A. Castro, Joshua P. Williford, Martin R. Cota, Judy M. MacLaren, Bernard J. Dardzinski, Lawrence L. Latour, Dzung L. Pham, John A. Butman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Traumatic meningeal injury is a novel imaging marker of traumatic brain injury, which appears as enhancement of the dura on post-contrast T2-weighted FLAIR images, and is likely associated with inflammation of the meninges. Dynamic Contrast Enhanced MRI provides a better discrimination of abnormally perfused regions. A method to properly identify those regions is presented. Images of seventeen patients scanned within 96 hours of head injury with positive traumatic meningeal injury were normalized and aligned. The difference between the pre- and last post-contrast acquisitions was segmented and voxels in the higher class were spatially clustered. Spatial and morphological descriptors were used to identify the regions of enhancement: a) centroid; b) distance to the brain mask from external voxels; c) distance from internal voxels; d) size; e) shape. The method properly identified thirteen regions among all patients. The method failed in one case due to the presence of a large brain lesion that altered the mask boundaries. Most false detections were correctly rejected resulting in a sensitivity and specificity of 92.9% and 93.6%, respectively.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2016
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor Gimi, Andrzej Krol
PublisherSPIE
ISBN (Electronic)9781510600232
DOIs
StatePublished - 2016
EventMedical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, United States
Duration: Mar 1 2016Mar 3 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9788
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego
Period3/1/163/3/16

Keywords

  • Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI)
  • Fluid-attenuated inversion recovery (FLAIR)
  • Image registration
  • Traumatic brain injury
  • Traumatic meningeal injury

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Quantification of traumatic meningeal injury using dynamic contrast enhanced (DCE) fluid-attenuated inversion recovery (FLAIR) imaging'. Together they form a unique fingerprint.

Cite this