Quantification of the source, amount and duration of aspiration in the lungs of infants using gamma scintigraphy

Beth L. Laube, Richard Katz, Gerald M. Loughlin, Jeanne M. Pinto, Maureen A. Lefton-Greif

Research output: Contribution to journalReview article

Abstract

Background: Aspiration can cause acute symptoms and chronic lung disease in the developing lung. However, the source of aspiration in infants is often unclear, making the choice of intervention difficult. Objective: To quantify the source, amount and duration of lung aspiration in infants using gamma scintigraphy. Methods: Two infants with clinical evidence of gastroesophageal reflux and oropharyngeal dysphagia swallowed formula radiolabeled with 99mtechnetium on Visit 1. Radiolabeled-formula was instilled by nasogastric tube on Visit 2. Lung aspiration was quantified over four hours and expressed as percent of total radioactivity administered. Results: Aspiration was greatest with swallowing, compared to instillation, peaking between 2.0% and 2.4% within 30 min and between 0.40% and 0.65% within 20 min, respectively. Radioactivity remained above zero four hours after either administration. Conclusions: Quantification of the source, amount and duration of lung aspiration in infants is feasible using gamma scintigraphy. The impact of aspiration accrual on clinical care deserves further investigation.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalPaediatric Respiratory Reviews
Volume32
DOIs
StatePublished - Nov 2019

Keywords

  • Gamma scintigraphy
  • Gastroesophageal reflux
  • Lung aspiration
  • Oropharyngeal dysphagia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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