Quantification of the association between intervertebral disk calcification and disk herniation in Dachshunds

Vibeke F. Jensen, Sarah Beck, Knud A. Christensen, Jens Arnbjerg

Research output: Contribution to journalArticle

Abstract

Objective - To quantify the association between intervertebral disk calcification and disk herniation in Dachshunds. Design - Longitudinal study. Animals - 61 Dachshunds that had been radlographically screened for calcification of intervertebral disks at 2 years of age in other studies. Thirty-seven of the dogs had survived to the time of the present study and were > 8 years of age; 24 others had not survived. Procedures - Radiographic examination of 36 surviving dogs was performed, and Information on occurrence of disk calcification at 2 years of age were obtained from records of all 61 Dachshunds. Information on occurrence of disk herniation between 2 and 8 years of age was obtained from owners via questionnaire, Associations between numbers of calcified disks and disk herniation were analyzed via maximum likelihood logistic regression. Results - Disk calcification at 2 years of age was a significant predictor of clinical disk herniation (odds ratio per calcified disk, 1.42; 95% confidence interval, 1.19 to 1.81). Number of calcified disks in the full vertebral column was a better predictor than number of calcified disks between vertebraeT10 and L3. Numbers of calcified disks at ≥ 8 years of age and at 2 years of age were significantly correlated. Conclusions and Clinical Relevance - Number of calcified disks at 2 years of age was a good predictor of clinical disk herniation in Dachshunds. Because of the high heritability of disk calcification, it is possible that an effective reduction In occurrence of severe disk herniation in Dachshunds could be obtained by selective breeding against high numbers of calcified disks at 2 years of age.

Original languageEnglish (US)
Pages (from-to)1090-1095
Number of pages6
JournalJournal of the American Veterinary Medical Association
Volume233
Issue number7
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

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Dachshund
intervertebral disks
Intervertebral Disc
calcification
Dogs
Longitudinal Studies
Spine
Logistic Models
Odds Ratio
Confidence Intervals
dogs
spine (bones)
selection methods
longitudinal studies
odds ratio
confidence interval
heritability
questionnaires
Selective Breeding
Surveys and Questionnaires

ASJC Scopus subject areas

  • veterinary(all)

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Quantification of the association between intervertebral disk calcification and disk herniation in Dachshunds. / Jensen, Vibeke F.; Beck, Sarah; Christensen, Knud A.; Arnbjerg, Jens.

In: Journal of the American Veterinary Medical Association, Vol. 233, No. 7, 01.10.2008, p. 1090-1095.

Research output: Contribution to journalArticle

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