TY - JOUR
T1 - Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile
AU - Verani, Mario S.
AU - Jeroudi, Mohamed O.
AU - Mahmarian, John J.
AU - Boyce, Terri M.
AU - Borges-Neto, Salvador
AU - Patel, Bharat
AU - Bolli, Roberto
N1 - Funding Information:
From the Section of Cardiology. Department of Medicine. Baylor College of Medicine and The Methodist Hospital. Houston. Texas. Computational assistance was provided by the CLINFO Project. funded by the Division of Research Resources of the National Institutes of Health . Bethesda. Maryland. under Grant RR-00350. *Dr. Borges-Neto was a research fellow funded by Conselho Nacional de Desenvolvimento Cieniifico e Tecnologico (CNPq). Brasilia. Brazil. This study was supported in part by Grant-in-Aid 87R-171 from the American Heart Association. Texas Affiliate. Austin. Texas. Manuscript received February 29. 1988; revised manuscript received June 29. 1988, accepted July 19, 1988. Address for reprints: Mario S. Verani, MD, The Methodist Hospital. 6535 Fannin, F-905, Houston, Texas 77030.
PY - 1988
Y1 - 1988
N2 - Myocardial imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile was investigated as a means to assess myocardial infarct size during coronary occlusion and to quantify the extent of salvaged myocardium after coronary occlusion followed by reperfusion. Open chest dogs underwent either a permanent coronary artery occlusion (Group 1, n = 16) or a 2 h occlusion followed by reperfusion (Group 2, n = 15). Animals in both groups were killed 48 h after occlusion. During coronary occlusion, 23 of the 25 dogs that survived the coronary occlusions had abnormal myocardial scintigrams. The scintigraphic perfusion defect size correlated well with the pathologic infarct size (r = 0.85 and 0.95 by planar and tomographic imaging, respectively). The planar scintigraphic defect size, but not the tomographic defect size, overestimated the pathologic size. The planar scintigraphic defect size observed during coronary occlusion was markedly reduced 48 h after reperfusion (24.8 ± 12.8% to 10.6 ± 9.7% of the left ventricle, p < 0.003). The uptake of technetium-99m hexakis 2-methoxyisobutyl isonitrile in the ischemic myocardium increased significantly 48 h after reperfusion (p < 0.003) and correlated with the increase in regional myocardial blood flow, as assessed by radioactive microspheres (r = 0.83, p < 0.01). Thus, myocardial imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile allows reliable demonstration of the presence of acute infarction, estimation of infarct size and quantification of the extent of salvaged myocardium after coronary reperfusion.
AB - Myocardial imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile was investigated as a means to assess myocardial infarct size during coronary occlusion and to quantify the extent of salvaged myocardium after coronary occlusion followed by reperfusion. Open chest dogs underwent either a permanent coronary artery occlusion (Group 1, n = 16) or a 2 h occlusion followed by reperfusion (Group 2, n = 15). Animals in both groups were killed 48 h after occlusion. During coronary occlusion, 23 of the 25 dogs that survived the coronary occlusions had abnormal myocardial scintigrams. The scintigraphic perfusion defect size correlated well with the pathologic infarct size (r = 0.85 and 0.95 by planar and tomographic imaging, respectively). The planar scintigraphic defect size, but not the tomographic defect size, overestimated the pathologic size. The planar scintigraphic defect size observed during coronary occlusion was markedly reduced 48 h after reperfusion (24.8 ± 12.8% to 10.6 ± 9.7% of the left ventricle, p < 0.003). The uptake of technetium-99m hexakis 2-methoxyisobutyl isonitrile in the ischemic myocardium increased significantly 48 h after reperfusion (p < 0.003) and correlated with the increase in regional myocardial blood flow, as assessed by radioactive microspheres (r = 0.83, p < 0.01). Thus, myocardial imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile allows reliable demonstration of the presence of acute infarction, estimation of infarct size and quantification of the extent of salvaged myocardium after coronary reperfusion.
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U2 - 10.1016/S0735-1097(88)80028-7
DO - 10.1016/S0735-1097(88)80028-7
M3 - Article
C2 - 2973483
AN - SCOPUS:0023698282
SN - 0735-1097
VL - 12
SP - 1573
EP - 1581
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 6
ER -