TY - GEN
T1 - Quantification of myocardial blood flow using the combination of bolus tracking and time-registered helical multidetector CT angiography during adenosine stress
AU - Ichihara, Takashi
AU - George, Richard T.
AU - Mather, Richard
AU - Silva, Caterina
AU - Lima, Joao A.C.
AU - Lardo, Albert C.
PY - 2010
Y1 - 2010
N2 - The purpose of this study was to develop a quantitative method for myocardial blood flow (MBF) measurement that can be used to derive accurate myocardial perfusion measurements from contrast-enhanced multidetector computed tomography (MDCT) images with bolus tracking and helical scanning. Nine canine models of left anterior descending artery (LAD) stenosis were prepared and underwent MDCT perfusion imaging during adenosine infusion (0.14-0.21 mg/kg/min) to study a wide range of flows. Neutron-activated microspheres were injected to document MBF during adenosine infusion. Six animals underwent dynamic MDCT perfusion imaging, and K1 and k2, which represent the first-order transfer constants from left ventricular blood to myocardium and from myocardium to the vascular system, respectively, were measured using a compartment model. The results were compared against microsphere MBF measurements, and the extraction fraction (E) of contrast agent and the mean value of K1/k2 were calculated. Six animals then underwent helical MDCT perfusion imaging during adenosine infusion. Prior to discontinuation of the
AB - The purpose of this study was to develop a quantitative method for myocardial blood flow (MBF) measurement that can be used to derive accurate myocardial perfusion measurements from contrast-enhanced multidetector computed tomography (MDCT) images with bolus tracking and helical scanning. Nine canine models of left anterior descending artery (LAD) stenosis were prepared and underwent MDCT perfusion imaging during adenosine infusion (0.14-0.21 mg/kg/min) to study a wide range of flows. Neutron-activated microspheres were injected to document MBF during adenosine infusion. Six animals underwent dynamic MDCT perfusion imaging, and K1 and k2, which represent the first-order transfer constants from left ventricular blood to myocardium and from myocardium to the vascular system, respectively, were measured using a compartment model. The results were compared against microsphere MBF measurements, and the extraction fraction (E) of contrast agent and the mean value of K1/k2 were calculated. Six animals then underwent helical MDCT perfusion imaging during adenosine infusion. Prior to discontinuation of the
UR - http://www.scopus.com/inward/record.url?scp=79960321649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960321649&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2010.5874252
DO - 10.1109/NSSMIC.2010.5874252
M3 - Conference contribution
AN - SCOPUS:79960321649
SN - 9781424491063
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 2573
EP - 2577
BT - IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
T2 - 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
Y2 - 30 October 2010 through 6 November 2010
ER -