Quantification of macular ischaemia in sickle cell retinopathy

C. M. Lee, H. C. Charles, R. T. Smith, N. S. Peachey, J. G. Cunha-Vaz, Morton F Goldberg

Research output: Contribution to journalArticle

Abstract

Macular ischaemia has a central role in the pathophysiology and prognosis of retinal macular disease. We attempted to quantitate two of its major components as follows: vascular non-perfusion, by measuring the foveal avascular zone (FAZ), using fluorescein angiography; and functional damage, using automated perimetry of the central 30°. Sickle cell disease was chosen for study because it was considered a prototype for a purely ischaemic retinopathy without an exudative component. We found that the FAZ measurement was reproducible and that the patients with maculopathy had statistically larger FAZs than the normal controls (p = 0.016, Wilcoxon rank sum test). In addition, scotomas measured by visual field perimetry were significantly larger in the sickle cell patients with maculopathty than in those without maculopathy. Our results showed that angiography and perimetry of the central 30° were more sensitive tests for the detection of ischaemic macular disease than visual acuity and that macular ischaemia could be quantified by their use.

Original languageEnglish (US)
Pages (from-to)540-545
Number of pages6
JournalBritish Journal of Ophthalmology
Volume71
Issue number7
StatePublished - 1987
Externally publishedYes

Fingerprint

Visual Field Tests
Ischemia
Nonparametric Statistics
Scotoma
Retinal Diseases
Fluorescein Angiography
Sickle Cell Anemia
Visual Fields
Visual Acuity
Blood Vessels
Angiography

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lee, C. M., Charles, H. C., Smith, R. T., Peachey, N. S., Cunha-Vaz, J. G., & Goldberg, M. F. (1987). Quantification of macular ischaemia in sickle cell retinopathy. British Journal of Ophthalmology, 71(7), 540-545.

Quantification of macular ischaemia in sickle cell retinopathy. / Lee, C. M.; Charles, H. C.; Smith, R. T.; Peachey, N. S.; Cunha-Vaz, J. G.; Goldberg, Morton F.

In: British Journal of Ophthalmology, Vol. 71, No. 7, 1987, p. 540-545.

Research output: Contribution to journalArticle

Lee, CM, Charles, HC, Smith, RT, Peachey, NS, Cunha-Vaz, JG & Goldberg, MF 1987, 'Quantification of macular ischaemia in sickle cell retinopathy', British Journal of Ophthalmology, vol. 71, no. 7, pp. 540-545.
Lee CM, Charles HC, Smith RT, Peachey NS, Cunha-Vaz JG, Goldberg MF. Quantification of macular ischaemia in sickle cell retinopathy. British Journal of Ophthalmology. 1987;71(7):540-545.
Lee, C. M. ; Charles, H. C. ; Smith, R. T. ; Peachey, N. S. ; Cunha-Vaz, J. G. ; Goldberg, Morton F. / Quantification of macular ischaemia in sickle cell retinopathy. In: British Journal of Ophthalmology. 1987 ; Vol. 71, No. 7. pp. 540-545.
@article{50bf1813d3a948eda28043e15b79ba60,
title = "Quantification of macular ischaemia in sickle cell retinopathy",
abstract = "Macular ischaemia has a central role in the pathophysiology and prognosis of retinal macular disease. We attempted to quantitate two of its major components as follows: vascular non-perfusion, by measuring the foveal avascular zone (FAZ), using fluorescein angiography; and functional damage, using automated perimetry of the central 30°. Sickle cell disease was chosen for study because it was considered a prototype for a purely ischaemic retinopathy without an exudative component. We found that the FAZ measurement was reproducible and that the patients with maculopathy had statistically larger FAZs than the normal controls (p = 0.016, Wilcoxon rank sum test). In addition, scotomas measured by visual field perimetry were significantly larger in the sickle cell patients with maculopathty than in those without maculopathy. Our results showed that angiography and perimetry of the central 30° were more sensitive tests for the detection of ischaemic macular disease than visual acuity and that macular ischaemia could be quantified by their use.",
author = "Lee, {C. M.} and Charles, {H. C.} and Smith, {R. T.} and Peachey, {N. S.} and Cunha-Vaz, {J. G.} and Goldberg, {Morton F}",
year = "1987",
language = "English (US)",
volume = "71",
pages = "540--545",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "7",

}

TY - JOUR

T1 - Quantification of macular ischaemia in sickle cell retinopathy

AU - Lee, C. M.

AU - Charles, H. C.

AU - Smith, R. T.

AU - Peachey, N. S.

AU - Cunha-Vaz, J. G.

AU - Goldberg, Morton F

PY - 1987

Y1 - 1987

N2 - Macular ischaemia has a central role in the pathophysiology and prognosis of retinal macular disease. We attempted to quantitate two of its major components as follows: vascular non-perfusion, by measuring the foveal avascular zone (FAZ), using fluorescein angiography; and functional damage, using automated perimetry of the central 30°. Sickle cell disease was chosen for study because it was considered a prototype for a purely ischaemic retinopathy without an exudative component. We found that the FAZ measurement was reproducible and that the patients with maculopathy had statistically larger FAZs than the normal controls (p = 0.016, Wilcoxon rank sum test). In addition, scotomas measured by visual field perimetry were significantly larger in the sickle cell patients with maculopathty than in those without maculopathy. Our results showed that angiography and perimetry of the central 30° were more sensitive tests for the detection of ischaemic macular disease than visual acuity and that macular ischaemia could be quantified by their use.

AB - Macular ischaemia has a central role in the pathophysiology and prognosis of retinal macular disease. We attempted to quantitate two of its major components as follows: vascular non-perfusion, by measuring the foveal avascular zone (FAZ), using fluorescein angiography; and functional damage, using automated perimetry of the central 30°. Sickle cell disease was chosen for study because it was considered a prototype for a purely ischaemic retinopathy without an exudative component. We found that the FAZ measurement was reproducible and that the patients with maculopathy had statistically larger FAZs than the normal controls (p = 0.016, Wilcoxon rank sum test). In addition, scotomas measured by visual field perimetry were significantly larger in the sickle cell patients with maculopathty than in those without maculopathy. Our results showed that angiography and perimetry of the central 30° were more sensitive tests for the detection of ischaemic macular disease than visual acuity and that macular ischaemia could be quantified by their use.

UR - http://www.scopus.com/inward/record.url?scp=0023268430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023268430&partnerID=8YFLogxK

M3 - Article

C2 - 3651368

AN - SCOPUS:0023268430

VL - 71

SP - 540

EP - 545

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 7

ER -