Quantification of edematic effects in prostate brachytherapy interventions

Mohamed Hefny, Purang Abolmaesumi, Zahra Karimaghaloo, David G. Gobbi, Randy Ellis, Gabor Fichtinger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a quantitative model to analyze the detrimental effects of edema on the quality of prostate brachytherapy implants. We account for both tissue expansion and implant migration by mapping intra-operative ultrasound and post-implant CT. We pre-process the ultrasound with a phase congruency filter, and map it to the volume CT using a B-spline deformable mutual information similarity metric. To test the method, we implanted a standard training phantom with 48 seeds, imaged the phantom with ultrasound and CT and registered the two for ground truth. Edema was simulated by distorting the CT volume by known transformations. The objective was to match the distorted implant to the intra-operative ultrasound. Performance was measured relative to ground truth. We successfully mapped 100% of deformed seeds to ground truth under edematic expansion up to 40% of volume growth. Seed matching performance was 98% with random seed migration of 3mm superimposed on 10% edematic volume growth. This method promises to be clinically applicable as the first quantitative analysis tool to measure edematic implant deformations occurring between the operating room and post-operative CT imaging.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages493-500
Number of pages8
Volume5242 LNCS
EditionPART 2
DOIs
StatePublished - 2008
Externally publishedYes
Event11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008 - New York, NY, United States
Duration: Sep 6 2008Sep 10 2008

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume5242 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008
CountryUnited States
CityNew York, NY
Period9/6/089/10/08

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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