Quantification of cat's articular afferents containing calcitonin gene- related peptide or substance P innervating normal and acutely inflamed knee joints

Yuan Xiang Tao, Feng Wei, Zhi Qi Zhao

Research output: Contribution to journalArticle

Abstract

In cats with an acute (32 h) unilateral knee joint inflammation the proportion of calcitonin gene-related peptide- (CGRP) and substance P-(SP) immunoreactive articular afferents, retrogradely labelled by Fast Blue (FB), were determined using immunohistochemistry. The proportion of neurons containing CGRP was significantly higher on the inflamed side (52%) than on the contralateral side (39%) and in controls (42%). However, the proportion of SP-immunoreactive articular perikarya on the inflamed side (26%) did not differ from the contralateral side (24%) and the control cats (22%). These data indicate that acute inflammation induces the synthesis of CGRP but not of SP in joint afferents.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalNeuroscience Letters
Volume233
Issue number2-3
DOIs
StatePublished - Sep 19 1997
Externally publishedYes

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Keywords

  • Arthritis
  • Calcitonin gene-related peptide
  • Cat
  • Dorsal root ganglia
  • Inflammation
  • Knee joint
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)

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