TY - JOUR
T1 - Quantification of brain μ-opioid receptors with [11C]carfentanil
T2 - Reference-tissue methods
AU - Endres, Christopher J.
AU - Bencherif, Badreddine
AU - Hilton, John
AU - Madar, Igal
AU - Frost, J. James
N1 - Funding Information:
The authors wish to thank Hayden Ravert, John Musachio, Bob Smoot, William Matthews, and Robert Dannals for radioisotope production and radiochemical synthesis, David Clough and Karen Edmonds for their assistance with the PET studies, and Alexis J. Simich for administrative support. This study was supported by NIH grants RO1 AA11855-01, and 1 RO1 AA11872-01A2.
PY - 2003/2
Y1 - 2003/2
N2 - [11C]Carfentanil (CFN) is a μ-opioid agonist used for in vivo positron emission tomography (PET) studies of μ-opioid receptors. Previously, a tissue-ratio method was validated for the quantification of CFN binding. However, since that initial validation, several other blood independent (reference-tissue) methods have become available. To evaluate these methods, CFN PET studies with arterial blood sampling were acquired in six healthy male control subjects. Specific binding estimates obtained from reference-tissue methods were compared to those obtained with a more rigorous blood input modeling technique. It was determined that both a graphical method, and a simplified reference tissue model, were more accurate than the tissue-ratio method for quantification of CFN binding.
AB - [11C]Carfentanil (CFN) is a μ-opioid agonist used for in vivo positron emission tomography (PET) studies of μ-opioid receptors. Previously, a tissue-ratio method was validated for the quantification of CFN binding. However, since that initial validation, several other blood independent (reference-tissue) methods have become available. To evaluate these methods, CFN PET studies with arterial blood sampling were acquired in six healthy male control subjects. Specific binding estimates obtained from reference-tissue methods were compared to those obtained with a more rigorous blood input modeling technique. It was determined that both a graphical method, and a simplified reference tissue model, were more accurate than the tissue-ratio method for quantification of CFN binding.
KW - Mu-opioid receptors
KW - Opiates
KW - Positron emission tomography
KW - [C]carfentanil
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U2 - 10.1016/S0969-8051(02)00411-0
DO - 10.1016/S0969-8051(02)00411-0
M3 - Article
C2 - 12623117
AN - SCOPUS:0037291759
SN - 0969-8051
VL - 30
SP - 177
EP - 186
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
IS - 2
ER -