Quality of life of patients with Takayasu's arteritis

Christopher Joseph Abularrage, Mark B. Slidell, Anton N. Sidawy, Peter Kreishman, Richard L. Amdur, Subodh Arora

Research output: Contribution to journalArticle

Abstract

Objective: Takayasu's arteritis (TA) is a chronic immune vasculitis that causes inflammation of the aorta and its branches and is clinically characterized by exacerbations and remissions. This study examined the quality of life (QoL) of patients with TA using the Medical Outcomes Study Short Form 36 (SF-36) Health Survey, a validated health related QoL questionnaire. Methods: Questionnaires that included the SF-36 and demographic related variables were mailed to 392 patients enrolled in the Takayasu's Arteritis Research Association. Raw SF-36 scores, as well as Physical Health Summary (PHS) and Mental Health Summary (MHS) scores, were calculated according to standard protocols. Data were analyzed for predictors of superior QoL using univariate and stepwise logistic regression analysis. SF-36 scores were also compared with those of other chronic diseases associated with peripheral vascular disease (PVD) published in the literature. Results are reported as mean ± standard error of the mean. Results: A total of 158 patients (144 women, 14 men) with average age of 42.2 ± 1.1 years responded to the questionnaire. Mean onset of symptoms occurred at 30.5 ± 1.2 years, with a mean age at diagnosis of 34.7 ± 1.2, and a median of four doctors were seen before diagnosis. The group underwent 299 TA-related surgical procedures (1.9 ± 0.3), including coronary (38%), carotid (35%), upper extremity (30%), and lower extremity (26%) revascularization. PHS and MHS summary scores (39.2 ± 1.0 and 44.5 ± 1.0, respectively) were worse than mean scores for an age-matched healthy population as well as nationally reported scores for diabetes mellitus, hypertension, and coronary artery disease (all P <.0001). Multivariate predictors of better physical QoL were younger age (P = .003) and remission of the disease (P = .0002). The use of immunomodulating medications was associated with inferior physical QoL (P = .02). The sole predictor of better mental QoL was remission of disease (P = .002). Conclusion: TA is a rare disease with profound consequences on QoL. Scores for physical and mental health are worse compared with many other chronic diseases associated with PVD. Superior physical QoL is seen in younger patients, whereas inferior physical QoL is encountered in those who take immunomodulating medications. Because the only factor to influence positively both physical and mental QoL is disease remission, every effort should be directed to attenuate disease activity.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalJournal of Vascular Surgery
Volume47
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Takayasu Arteritis
Quality of Life
Mental Health
Peripheral Vascular Diseases
Chronic Disease
Health
Rare Diseases
Vasculitis
Health Surveys
Upper Extremity
Aorta
Coronary Artery Disease
Lower Extremity
Diabetes Mellitus
Logistic Models
Regression Analysis
Demography
Outcome Assessment (Health Care)
Hypertension
Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Abularrage, C. J., Slidell, M. B., Sidawy, A. N., Kreishman, P., Amdur, R. L., & Arora, S. (2008). Quality of life of patients with Takayasu's arteritis. Journal of Vascular Surgery, 47(1), 131-137. https://doi.org/10.1016/j.jvs.2007.09.044

Quality of life of patients with Takayasu's arteritis. / Abularrage, Christopher Joseph; Slidell, Mark B.; Sidawy, Anton N.; Kreishman, Peter; Amdur, Richard L.; Arora, Subodh.

In: Journal of Vascular Surgery, Vol. 47, No. 1, 01.2008, p. 131-137.

Research output: Contribution to journalArticle

Abularrage, CJ, Slidell, MB, Sidawy, AN, Kreishman, P, Amdur, RL & Arora, S 2008, 'Quality of life of patients with Takayasu's arteritis', Journal of Vascular Surgery, vol. 47, no. 1, pp. 131-137. https://doi.org/10.1016/j.jvs.2007.09.044
Abularrage, Christopher Joseph ; Slidell, Mark B. ; Sidawy, Anton N. ; Kreishman, Peter ; Amdur, Richard L. ; Arora, Subodh. / Quality of life of patients with Takayasu's arteritis. In: Journal of Vascular Surgery. 2008 ; Vol. 47, No. 1. pp. 131-137.
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N2 - Objective: Takayasu's arteritis (TA) is a chronic immune vasculitis that causes inflammation of the aorta and its branches and is clinically characterized by exacerbations and remissions. This study examined the quality of life (QoL) of patients with TA using the Medical Outcomes Study Short Form 36 (SF-36) Health Survey, a validated health related QoL questionnaire. Methods: Questionnaires that included the SF-36 and demographic related variables were mailed to 392 patients enrolled in the Takayasu's Arteritis Research Association. Raw SF-36 scores, as well as Physical Health Summary (PHS) and Mental Health Summary (MHS) scores, were calculated according to standard protocols. Data were analyzed for predictors of superior QoL using univariate and stepwise logistic regression analysis. SF-36 scores were also compared with those of other chronic diseases associated with peripheral vascular disease (PVD) published in the literature. Results are reported as mean ± standard error of the mean. Results: A total of 158 patients (144 women, 14 men) with average age of 42.2 ± 1.1 years responded to the questionnaire. Mean onset of symptoms occurred at 30.5 ± 1.2 years, with a mean age at diagnosis of 34.7 ± 1.2, and a median of four doctors were seen before diagnosis. The group underwent 299 TA-related surgical procedures (1.9 ± 0.3), including coronary (38%), carotid (35%), upper extremity (30%), and lower extremity (26%) revascularization. PHS and MHS summary scores (39.2 ± 1.0 and 44.5 ± 1.0, respectively) were worse than mean scores for an age-matched healthy population as well as nationally reported scores for diabetes mellitus, hypertension, and coronary artery disease (all P <.0001). Multivariate predictors of better physical QoL were younger age (P = .003) and remission of the disease (P = .0002). The use of immunomodulating medications was associated with inferior physical QoL (P = .02). The sole predictor of better mental QoL was remission of disease (P = .002). Conclusion: TA is a rare disease with profound consequences on QoL. Scores for physical and mental health are worse compared with many other chronic diseases associated with PVD. Superior physical QoL is seen in younger patients, whereas inferior physical QoL is encountered in those who take immunomodulating medications. Because the only factor to influence positively both physical and mental QoL is disease remission, every effort should be directed to attenuate disease activity.

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