Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis

Owen Dean, Seher Anjum, Terri Scott, Lillian Ham, Katherine Traino, Jing Wang, Sally Hunsberger, John H. Powers, Kieren A. Marr, Joseph Snow, Peter R. Williamson

Research output: Contribution to journalArticlepeer-review

Abstract

The morbidity and mortality of cryptococcal meningoencephalitis (CM) in previously healthy, HIV-negative individuals is increasingly recognized. We administered a healthcare associated quality of life (QOL) survey to the largest longitudinally followed cohort of these patients in the United States. We identified moderate or severe self-reported impairment in at least one QOL domain in 61% of subjects at least one year following diagnosis. Self-reported cognitive impairment was noted in 52% and sleep disturbance was noted in 55%. This is the first comprehensive study of cross-sectional long-term QOL in previously healthy patients following cryptococcal infection.

Original languageEnglish (US)
Article number3673
JournalScientific reports
Volume11
Issue number1
DOIs
StatePublished - Dec 2021

ASJC Scopus subject areas

  • General

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