@article{2b433badbc8c44ce9ac4384e29c34681,
title = "Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis",
abstract = "The morbidity and mortality of cryptococcal meningoencephalitis (CM) in previously healthy, HIV-negative individuals is increasingly recognized. We administered a healthcare associated quality of life (QOL) survey to the largest longitudinally followed cohort of these patients in the United States. We identified moderate or severe self-reported impairment in at least one QOL domain in 61% of subjects at least one year following diagnosis. Self-reported cognitive impairment was noted in 52% and sleep disturbance was noted in 55%. This is the first comprehensive study of cross-sectional long-term QOL in previously healthy patients following cryptococcal infection.",
author = "Owen Dean and Seher Anjum and Terri Scott and Lillian Ham and Katherine Traino and Jing Wang and Sally Hunsberger and Powers, {John H.} and Marr, {Kieren A.} and Joseph Snow and Williamson, {Peter R.}",
note = "Funding Information: OD is supported by the NIH Medical Research Scholars Program, a public–private partnership supported jointly by the NIH and contributions to the Foundation for the NIH from the Doris Duke Charitable Foundation, Genentech, the American Association for Dental Research, the Colgate-Palmolive Company, and other private donors. This work was also supported by NIAID UO1 AI109657 and the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD (PRW, SA, AI001123 and AO001124), and the National Cancer Institute (Contract No. 75N91019D00024, Task Order No. 75N91019F00130). TS, JW, SH, JHP, JS are also supported by the NIH Intramural Research Program of the respective institutes. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Parts of this work were presented at Infectious Diseases Society of America IDWeek 2020. Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
doi = "10.1038/s41598-021-83176-2",
language = "English (US)",
volume = "11",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}