Quality of life in HIV-infected individuals receiving antiretroviral therapy is related to adherence

Sharon B. Mannheimer, J. Matts, E. Telzak, M. Chesney, C. Child, Albert W Wu, G. Friedland

Research output: Contribution to journalArticle

Abstract

This study assesses changes in quality of life (QoL) over time among HIV-infected individuals receiving antiretroviral therapy (ART) and evaluates how this relates to ART adherence. Prospective, longitudinal data were examined from 1050 participants in two large, randomized, multi-centre antiretroviral clinical trials. QoL was assessed by the SF-12; adherence by the Terry Beirn Community Programs for Clinical Research on AIDS Antiretroviral Medication Self-report. Participants included 20% women, 53% African Americans, 16% Latinos; mean age was 39 years; mean baseline CD4+ cell count 230 cells/mm 3; 89% were ART-naïve at entry. Baseline physical and mental health summary QoL scores were 45.4 and 42.9, comparable to scores reported in other advanced HIV populations. Significant improvements in mean QoL scores were seen for the group as a whole after 1 to 4 months on new ART regimens, and persisted for 12 months. Participants reporting 100% ART adherence achieved significantly higher QoL scores at 12 months compared to those with poorer adherence, particularly if 100% adherence was consistent (p

Original languageEnglish (US)
Pages (from-to)10-22
Number of pages13
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Volume17
Issue number1
DOIs
StatePublished - Jan 2005

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quality of life
Quality of Life
HIV
Therapeutics
CD4 Lymphocyte Count
Hispanic Americans
African Americans
Self Report
Mental Health
Acquired Immunodeficiency Syndrome
AIDS
medication
mental health
Clinical Trials
Research
Population
community
Group

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Health Professions(all)
  • Social Sciences (miscellaneous)

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Quality of life in HIV-infected individuals receiving antiretroviral therapy is related to adherence. / Mannheimer, Sharon B.; Matts, J.; Telzak, E.; Chesney, M.; Child, C.; Wu, Albert W; Friedland, G.

In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, Vol. 17, No. 1, 01.2005, p. 10-22.

Research output: Contribution to journalArticle

Mannheimer, Sharon B. ; Matts, J. ; Telzak, E. ; Chesney, M. ; Child, C. ; Wu, Albert W ; Friedland, G. / Quality of life in HIV-infected individuals receiving antiretroviral therapy is related to adherence. In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV. 2005 ; Vol. 17, No. 1. pp. 10-22.
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