@article{fdd4c5858cb949e2a2fc90475ed50863,
title = "Quality of Life in Children and Youth with Obsessive-Compulsive Disorder",
abstract = "Objective: The study examined clinical correlates of quality of life (QoL), impact of treatment on QoL, and predictors of QoL change among children with obsessive-compulsive disorder (OCD). Methods: One hundred forty-two children with primary OCD who were enrolled as part of a larger clinical trial participated. Children were administered a structured diagnostic interview, as well as clinician-administered measures of OCD and depression symptom severity. Children and parents completed reports of QoL, as well as measures of impairment and internalizing and externalizing symptoms. Youth received 10 sessions of family-based cognitive-behavioral therapy (CBT). Results: At baseline, QoL was inversely related to obsessive-compulsive symptom severity, impairment, externalizing and internalizing symptoms, and severity of depression symptoms according to children and parents. After CBT, QoL improved according to parent ratings, but not child ratings. None of the predictors examined were associated with changes in QoL scores over time. Impairment, and externalizing and internalizing symptoms predicted QoL after accounting for OCD symptom severity. After accounting for OCD symptoms, externalizing symptoms inversely predicted changes in QoL. Conclusion: These data suggest that QoL is related to more severe clinical presentation and improves with evidence-based treatment, but QoL improvements may be inversely related to externalizing symptomology.",
keywords = "adolescents, assessment, children, cognitive-behavioral therapy, obsessive-compulsive disorder, quality of life, treatment",
author = "Storch, {Eric A.} and Small, {Brent J.} and McGuire, {Joseph F.} and Murphy, {Tanya K.} and Sabine Wilhelm and Geller, {Daniel A.}",
note = "Funding Information: Dr. Storch reported receiving research support from the National Institutes of Health, International OCD Foundation, and All Children{\textquoteright}s Hospital Research Foundation; reported receiving royalties from Elsevier Publications, Springer, American Psychological Association, John Wiley & Sons Inc, and Lawrence Erlbaum; reported being a consultant for Rijuin Hospital in China; reported serving on the speaker{\textquoteright}s bureau and scientific advisory board for the International OCD Foundation; and reported receiving research support from the All Children{\textquoteright}s Hospital Guild Endowed Chair. Dr. Small reports nothing to disclose. Dr. McGuire reported receiving grant funding from the Tourette Association of America and National Institutes of Health. Dr. Wilhelm reported receiving research support in the form of free medication and matching placebo from Forest Laboratories for a National Institute of Mental Health–funded clinical trial; reported being a presenter for the Massachusetts General Hospital Psychiatry Academy in educational programs supported through independent medical education grants from pharmaceutical companies; reported receiving royalties from Elsevier Publications, Guilford Publications, and New Harbinger Publications; reported receiving salary support from Novartis; reported receiving speaking honoraria from various academic institutions and foundations, including the International OCD Foundation and Tourette Association of America; and reported receiving payment from the Association for Behavioral and Cognitive Therapies for her role as associate editor for the Behavior Therapy journal, as well as from John Wiley & Sons Inc for her role as associate editor for the Depression and Anxiety journal. Dr. Murphy reported receiving research funding from Auspex Pharmaceuticals, National Institute of Mental Health, Shire Pharmaceuticals, Pfizer, F. Hoffmann–La Roche Ltd., AstraZeneca Pharmaceuticals, Centers for Disease Control and Prevention, Massachusetts General Hospital, Sunovion Pharmaceuticals, Neurocrine Biosciences, PANDAS Network, and Psyadon Pharmaceuticals. Dr. Geller reported receiving grant support from the National Institutes of Health and a book honorarium from the American Academy of Child and Adolescent Psychiatry; reported receiving speaking honoraria for Advanced Institute lectures from the American Academy of Child and Adolescent Psychiatry and Massachusetts General Hospital Psychiatry Academy in educational programs supported through independent medical education grants from pharmaceutical companies; and reported receiving lifetime funding support from the International OCD Foundation, Tourette Association of America, McIng-vale Family Foundation, Eli Lilly, Pfizer, and GlaxoSmithKline. Publisher Copyright: {\textcopyright} Copyright 2018, Mary Ann Liebert, Inc.",
year = "2018",
month = mar,
doi = "10.1089/cap.2017.0091",
language = "English (US)",
volume = "28",
pages = "104--110",
journal = "Journal of child and adolescent psychopharmacology",
issn = "1044-5463",
publisher = "Mary Ann Liebert Inc.",
number = "2",
}