Quality of life in a placebo-controlled trial of zidovudine in patients with aids and aids-related complex

Albert W Wu, William C. Mathews, Lucy T. Brysk, J. Hampton Atkinson, Igor Grant, Ian Abramson, Caroline J. Kennedy, J. Allen McCutchan, Stephen A. Spector, Douglas D. Richman

Research output: Contribution to journalArticle

Abstract

We measured quality of life using the Karnofsky Performance Status and Quality of Weil-Being scale (QWB) for 31 patients with AIDS and AIDS-related complex in a placebo-controlled trial of zidovudine. Sixteen patients were randomized to zidovudine and 15 to placebo. We recorded nine scores for each patient during 1 year. During the blinded trial, 3 patients receiving placebo died; at 1 year, one had died in the zidovudine group and 10 in the placebo group. Repeated-measures analysis of variance demonstrated that mean scores declined less for the zidovudine group than for the placebo group during the blinded trial (p

Original languageEnglish (US)
Pages (from-to)683-690
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume3
Issue number7
StatePublished - 1990
Externally publishedYes

Fingerprint

Zidovudine
Placebos
Quality of Life
AIDS-Related Complex
Karnofsky Performance Status
Analysis of Variance
Acquired Immunodeficiency Syndrome

Keywords

  • Clinical trials
  • Functional status
  • Karnofsky Performance Status
  • Outcome
  • Quality of life
  • Quality of Weil-Being scale
  • Zidovudine

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Immunology and Allergy
  • Virology

Cite this

Wu, A. W., Mathews, W. C., Brysk, L. T., Atkinson, J. H., Grant, I., Abramson, I., ... Richman, D. D. (1990). Quality of life in a placebo-controlled trial of zidovudine in patients with aids and aids-related complex. Journal of Acquired Immune Deficiency Syndromes, 3(7), 683-690.

Quality of life in a placebo-controlled trial of zidovudine in patients with aids and aids-related complex. / Wu, Albert W; Mathews, William C.; Brysk, Lucy T.; Atkinson, J. Hampton; Grant, Igor; Abramson, Ian; Kennedy, Caroline J.; McCutchan, J. Allen; Spector, Stephen A.; Richman, Douglas D.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 3, No. 7, 1990, p. 683-690.

Research output: Contribution to journalArticle

Wu, AW, Mathews, WC, Brysk, LT, Atkinson, JH, Grant, I, Abramson, I, Kennedy, CJ, McCutchan, JA, Spector, SA & Richman, DD 1990, 'Quality of life in a placebo-controlled trial of zidovudine in patients with aids and aids-related complex', Journal of Acquired Immune Deficiency Syndromes, vol. 3, no. 7, pp. 683-690.
Wu, Albert W ; Mathews, William C. ; Brysk, Lucy T. ; Atkinson, J. Hampton ; Grant, Igor ; Abramson, Ian ; Kennedy, Caroline J. ; McCutchan, J. Allen ; Spector, Stephen A. ; Richman, Douglas D. / Quality of life in a placebo-controlled trial of zidovudine in patients with aids and aids-related complex. In: Journal of Acquired Immune Deficiency Syndromes. 1990 ; Vol. 3, No. 7. pp. 683-690.
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