Quality and quantity: New strategies to improve immunotherapy of cancer

Christine Krueger, Jonathan P. Schneck, Mathias Oelke

Research output: Contribution to journalShort surveypeer-review

Abstract

Adoptive immunotherapy is a promising approach for the treatment of infectious diseases and cancer. Several lines of research are currently focusing on the development of different technologies to facilitate the induction and expansion of antigen-specific T cells. Here, we discuss two current articles that affect the field of adoptive immunotherapy. One article describes the engineering of artificial antigen-presenting cells, which promise to replace the cumbersome dendritic-cell approach for the in vitro generation of large numbers of antigen-specific T cells. The second development is a description of a new technique for the detection of functionally active antigen-specific T cells, which will enhance the ability to control the quality of the T cells to be used in adoptive immunotherapy. Together, these exciting findings will advance the field of immunotherapy.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalTrends in Molecular Medicine
Volume10
Issue number5
DOIs
StatePublished - May 1 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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