Qualitative differences between dimeric and trimeric stimulation of human basophils

D. W. MacGlashan, R. P. Schleimer, L. M. Lichtenstein

Research output: Contribution to journalArticle

Abstract

Previous studies from this laboratory demonstrated differences between antigenic and anti-IgE antibody stimulation of human basophilis under the pharmacologic control of indomethacin. We show here that this difference may be due to the type of aggregation these stimuli induce on the cell surface. We found that the synthetically cross-linked trimer of IgE caused histamine release that was enhanced by indomethacin, whereas dimeric IgE induced-release was not. This result was not due to a difference in the kinetics of release by these two stimuli. These results suggest that the state of aggregation of Fc receptors differentially affects various cellular enzyme systems.

Original languageEnglish (US)
Pages (from-to)4-6
Number of pages3
JournalJournal of Immunology
Volume130
Issue number1
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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