Quadriceps strength, quadriceps power, and gait speed in older U.S. adults with diabetes mellitus: Results from the National Health and Nutrition Examination Survey, 1999-2002

Rita Rastogi Kalyani, Yolande Tra, Hsin Chieh Yeh, Josephine M. Egan, Luigi Ferrucci, Frederick Louis Brancati

Research output: Contribution to journalReview article

Abstract

Objectives To examine the independent association between diabetes mellitus (and its duration and severity) and quadriceps strength, quadriceps power, and gait speed in a national population of older adults. Design Cross-sectional nationally representative survey. Setting United States. Participants Two thousand five hundred seventy-three adults aged 50 and older in the National Health and Nutrition Examination Survey 1999-2002 who had assessment of quadriceps strength. Methods Diabetes mellitus was ascertained according to questionnaire. Measurement of isokinetic knee extensor (quadriceps) strength was performed at 60°/s. Gait speed was assessed using a 20-foot walk test. Multiple linear regression analyses were used to assess the association between diabetes mellitus status and outcomes, adjusting for potential confounders or mediators. Results Older U.S. adults with diabetes mellitus had significantly slower gait speed (0.96 ± 0.02 m/s) than those without (1.08 ± 0.01 m/s; P <.001). After adjusting for demographic characteristics, weight, and height, diabetes mellitus was also associated with significantly lower quadriceps strength (-4.6 ± 1.9 Nm; P =.02) and power (-4.9 ± 2.0 W; P =.02) and slower gait speed (-0.05 ± 0.02 m/s; P =.002). Associations remained significant after adjusting for physical activity and C-reactive protein. After accounting for comorbidities (cardiovascular disease, peripheral neuropathy, amputation, cancer, arthritis, fracture, chronic obstructive pulmonary disease), diabetes mellitus was independently associated only with gait speed (-0.04 ± 0.02 m/s; P =.02). Diabetes mellitus duration in men and women was negatively associated with age-adjusted quadriceps strength (-5.7 and -3.5 Nm/decade of diabetes mellitus, respectively) and power (-6.1 and -3.8 W/decade of diabetes mellitus, respectively) (all P ≤.001, no significant interactions according to sex). Glycosylated hemoglobin was not associated with outcomes after accounting for body weight. Conclusion Older U.S. adults with diabetes mellitus have lower quadriceps strength and quadriceps power that is related to the presence of comorbidities and walk slower than those without diabetes mellitus. Future studies should investigate the relationship between hyperglycemia and subsequent declines in leg muscle function.

Original languageEnglish (US)
Pages (from-to)769-775
Number of pages7
JournalJournal of the American Geriatrics Society
Volume61
Issue number5
DOIs
StatePublished - May 27 2013

Keywords

  • gait
  • muscle loss
  • physical function
  • type 2 diabetes mellitus

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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