TY - JOUR
T1 - QTc interval prolongation by d-propoxyphene
T2 - What about other analgesics?
AU - Raffa, Robert B.
AU - Burmeister, Jeffrey J.
AU - Yuvasheva, Ekaterina
AU - Pergolizzi, Joseph V.
PY - 2012/7
Y1 - 2012/7
N2 - Introduction: d-Propoxyphene, which was previously available in many single-agent and combination products, was recently voluntarily withdrawn from the US market following an FDA recommendation based partly on the concern that the risk associated with QT prolongation exceeded the clinical benefit of the drug. The drug had previously been withdrawn from European markets. These recent actions prompt the question: what is known about QT prolongation and analgesic drugs? Areas covered: A systematic search was conducted of 50 opioid and non-opioid analgesic drugs using PubMed, the FDA website, and the Internet. Search terms for opioids, NSAIDs, acetaminophen and other analgesics were used (including both generic and brand names), along with QTc, QTc prolongation, QTc interval, hERG, torsades de pointes (TdP), ventricular arrhythmias, and other relevant terms. Expert opinion: There is a paucity of available information on the QT interval for most analgesics. Of those for which there is a lot of data, only methadone, oxycodone, and LAAM (levo - acetylmethadol) appear to have a known and accepted level of effect on the QT interval.
AB - Introduction: d-Propoxyphene, which was previously available in many single-agent and combination products, was recently voluntarily withdrawn from the US market following an FDA recommendation based partly on the concern that the risk associated with QT prolongation exceeded the clinical benefit of the drug. The drug had previously been withdrawn from European markets. These recent actions prompt the question: what is known about QT prolongation and analgesic drugs? Areas covered: A systematic search was conducted of 50 opioid and non-opioid analgesic drugs using PubMed, the FDA website, and the Internet. Search terms for opioids, NSAIDs, acetaminophen and other analgesics were used (including both generic and brand names), along with QTc, QTc prolongation, QTc interval, hERG, torsades de pointes (TdP), ventricular arrhythmias, and other relevant terms. Expert opinion: There is a paucity of available information on the QT interval for most analgesics. Of those for which there is a lot of data, only methadone, oxycodone, and LAAM (levo - acetylmethadol) appear to have a known and accepted level of effect on the QT interval.
KW - Analgesics
KW - HERG
KW - Non-opioids
KW - Opioids
KW - QT interval
UR - http://www.scopus.com/inward/record.url?scp=84863098538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863098538&partnerID=8YFLogxK
U2 - 10.1517/14656566.2012.682150
DO - 10.1517/14656566.2012.682150
M3 - Article
C2 - 22568597
AN - SCOPUS:84863098538
SN - 1465-6566
VL - 13
SP - 1397
EP - 1409
JO - Expert Opinion on Pharmacotherapy
JF - Expert Opinion on Pharmacotherapy
IS - 10
ER -