Abstract
Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 μg/ml and 0.13 μg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.
Original language | English (US) |
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Pages (from-to) | 4495-4497 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 51 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2007 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases