Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister mycobacterium tuberculosis

Sean T. Byrne, Peihua Gu, Jiangbing Zhou, Steven M. Denkin, Curtis Chong, David Sullivan, Jun O. Liu, Ying Zhang

Research output: Contribution to journalArticle

Abstract

Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 μg/ml and 0.13 μg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.

Original languageEnglish (US)
Pages (from-to)4495-4497
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number12
DOIs
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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