Abstract
Delayed diagnosis of drug resistance has been a major obstacle to proper management and control of drug-resistant tuberculosis (TB). Expanded access to rapid molecular diagnostics such as Xpert MTB/RIF has been helpful, but has generated confusion about how to interpret genotype-phenotype discordance. Optimal management is not clearly defined for patients with rifampin resistance by Xpert MTB/RIF but rifampin susceptibility by phenotypic testing. To resolve this discrepancy, we performed pyrosequencing of discordant isolates identified at a reference laboratory over a 6-month period. We present here strategies to address genotype-phenotype discordance using sequencing.
Original language | English (US) |
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Pages (from-to) | 168-170 |
Number of pages | 3 |
Journal | Lung India |
Volume | 35 |
Issue number | 2 |
DOIs | |
State | Published - Mar 1 2018 |
Keywords
- Culture
- Discrepancy
- Pyrosequencing
- Xpert
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine