Pyridoxine deficiency and ethanol-induced liver injury

A. M. Diehl, M. A. Chacon, James John Potter, D. Rolfes, D. F. Cruess, Esteban Mezey

Research output: Contribution to journalArticle

Abstract

It has been suggested that pyridoxine deficiency may potentiate ethanol-induced liver injury. Our purpose was to clarify the effect of pyridoxine deficiency on ethanol-associated liver injury by comparing liver histology, serum liver enzymes, and the viability of cultured hepatocytes from pyridoxine-deficient and pyridoxine-sufficient rats that had been chronically fed ethanol-enriched diets. Our data fail to substantiate that pyridoxine-deficient animals are more susceptible to the hepatotoxic effect of ethanol than pair-fed pyridoxine-sufficient controls. Furthermore, the addition of pyridoxine to hepatocyte cultures fails to prevent in vitro cytoxicity of added ethanol. Pyridoxine deficiency may augment ethanol-induced enhancement of hepatic urea synthesis. These data suggest that pyridoxine deficiency may contribute to the abnormal plasma amino acid profiles and nitrogen balance of chronic alcoholics, but that it does not potentiate ethanol-induced liver injury.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume11
Issue number4
StatePublished - 1987

Fingerprint

Vitamin B 6 Deficiency
Pyridoxine
Liver
Ethanol
Wounds and Injuries
Hepatocytes
Alcoholics
Histology
Urea
Nutrition
Nitrogen
Diet
Rats
Amino Acids
Animals
Enzymes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Pyridoxine deficiency and ethanol-induced liver injury. / Diehl, A. M.; Chacon, M. A.; Potter, James John; Rolfes, D.; Cruess, D. F.; Mezey, Esteban.

In: Alcoholism: Clinical and Experimental Research, Vol. 11, No. 4, 1987, p. 385-391.

Research output: Contribution to journalArticle

Diehl, AM, Chacon, MA, Potter, JJ, Rolfes, D, Cruess, DF & Mezey, E 1987, 'Pyridoxine deficiency and ethanol-induced liver injury', Alcoholism: Clinical and Experimental Research, vol. 11, no. 4, pp. 385-391.
Diehl, A. M. ; Chacon, M. A. ; Potter, James John ; Rolfes, D. ; Cruess, D. F. ; Mezey, Esteban. / Pyridoxine deficiency and ethanol-induced liver injury. In: Alcoholism: Clinical and Experimental Research. 1987 ; Vol. 11, No. 4. pp. 385-391.
@article{7d80ea5f873f4d69a658938cbc1f3a63,
title = "Pyridoxine deficiency and ethanol-induced liver injury",
abstract = "It has been suggested that pyridoxine deficiency may potentiate ethanol-induced liver injury. Our purpose was to clarify the effect of pyridoxine deficiency on ethanol-associated liver injury by comparing liver histology, serum liver enzymes, and the viability of cultured hepatocytes from pyridoxine-deficient and pyridoxine-sufficient rats that had been chronically fed ethanol-enriched diets. Our data fail to substantiate that pyridoxine-deficient animals are more susceptible to the hepatotoxic effect of ethanol than pair-fed pyridoxine-sufficient controls. Furthermore, the addition of pyridoxine to hepatocyte cultures fails to prevent in vitro cytoxicity of added ethanol. Pyridoxine deficiency may augment ethanol-induced enhancement of hepatic urea synthesis. These data suggest that pyridoxine deficiency may contribute to the abnormal plasma amino acid profiles and nitrogen balance of chronic alcoholics, but that it does not potentiate ethanol-induced liver injury.",
author = "Diehl, {A. M.} and Chacon, {M. A.} and Potter, {James John} and D. Rolfes and Cruess, {D. F.} and Esteban Mezey",
year = "1987",
language = "English (US)",
volume = "11",
pages = "385--391",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Pyridoxine deficiency and ethanol-induced liver injury

AU - Diehl, A. M.

AU - Chacon, M. A.

AU - Potter, James John

AU - Rolfes, D.

AU - Cruess, D. F.

AU - Mezey, Esteban

PY - 1987

Y1 - 1987

N2 - It has been suggested that pyridoxine deficiency may potentiate ethanol-induced liver injury. Our purpose was to clarify the effect of pyridoxine deficiency on ethanol-associated liver injury by comparing liver histology, serum liver enzymes, and the viability of cultured hepatocytes from pyridoxine-deficient and pyridoxine-sufficient rats that had been chronically fed ethanol-enriched diets. Our data fail to substantiate that pyridoxine-deficient animals are more susceptible to the hepatotoxic effect of ethanol than pair-fed pyridoxine-sufficient controls. Furthermore, the addition of pyridoxine to hepatocyte cultures fails to prevent in vitro cytoxicity of added ethanol. Pyridoxine deficiency may augment ethanol-induced enhancement of hepatic urea synthesis. These data suggest that pyridoxine deficiency may contribute to the abnormal plasma amino acid profiles and nitrogen balance of chronic alcoholics, but that it does not potentiate ethanol-induced liver injury.

AB - It has been suggested that pyridoxine deficiency may potentiate ethanol-induced liver injury. Our purpose was to clarify the effect of pyridoxine deficiency on ethanol-associated liver injury by comparing liver histology, serum liver enzymes, and the viability of cultured hepatocytes from pyridoxine-deficient and pyridoxine-sufficient rats that had been chronically fed ethanol-enriched diets. Our data fail to substantiate that pyridoxine-deficient animals are more susceptible to the hepatotoxic effect of ethanol than pair-fed pyridoxine-sufficient controls. Furthermore, the addition of pyridoxine to hepatocyte cultures fails to prevent in vitro cytoxicity of added ethanol. Pyridoxine deficiency may augment ethanol-induced enhancement of hepatic urea synthesis. These data suggest that pyridoxine deficiency may contribute to the abnormal plasma amino acid profiles and nitrogen balance of chronic alcoholics, but that it does not potentiate ethanol-induced liver injury.

UR - http://www.scopus.com/inward/record.url?scp=0023201433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023201433&partnerID=8YFLogxK

M3 - Article

C2 - 3307510

AN - SCOPUS:0023201433

VL - 11

SP - 385

EP - 391

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 4

ER -