LE PYRAZINAMIDE DANS LE TRAITEMENT DE COURTE DUREE DE LA TUBERCULOSE MURINE

Translated title of the contribution: Pyrazinamide in short course chemotherapy of murine tuberculosis

F. Grumbach, J. Grosset

Research output: Contribution to journalArticlepeer-review

Abstract

The incorporation of pyrazinamide into standard drug schemes for the short course treatment of pulmonary tuberculosis was found to be highly effective. 4 different regimens were applied daily in mice with advanced tuberculosis. These were: isoniazid + pyrazinamide, isoniazid + rifampicin, isoniazid + streptomycin + pyrazinamide, isoniazid + streptomycin + rifampicin. All regimens produced negative cultures at the end of 6 mth in all animals treated. The most effective of them was the first triple combination, which gave 100% negative cultures after 3 mth. 6 mth after termination of any of the combinations, 80% of the animals remained negative regardless of regimen. Complementary 2 phase regimens were also studied. In a first intensive phase, a combination of isoniazid and pyrazinamide was administered daily for 1-3 mth. The second phase consisted of daily isoniazid alone or isoniazid and pyrazinamide twice a wk. The longer the initial phase of daily combined chemotherapy the better the final result of the 2 phase treatment. Whether the first phase lasted 1, 2 or 3 mth, the twice weekly isoniazid plus pyrazinamide regimen is, in the second phase, more effective than the daily isoniazid regimen. After 3 mth of continuous treatment, twice weekly isoniazid plus pyrazinamide gave 100% negative cultures.

Translated title of the contributionPyrazinamide in short course chemotherapy of murine tuberculosis
Original languageFrench
Pages (from-to)5-18
Number of pages14
JournalRevue Francaise des Maladies Respiratoires
Volume3
Issue number1
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Medicine(all)

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