The incorporation of pyrazinamide into standard drug schemes for the short course treatment of pulmonary tuberculosis was found to be highly effective. 4 different regimens were applied daily in mice with advanced tuberculosis. These were: isoniazid + pyrazinamide, isoniazid + rifampicin, isoniazid + streptomycin + pyrazinamide, isoniazid + streptomycin + rifampicin. All regimens produced negative cultures at the end of 6 mth in all animals treated. The most effective of them was the first triple combination, which gave 100% negative cultures after 3 mth. 6 mth after termination of any of the combinations, 80% of the animals remained negative regardless of regimen. Complementary 2 phase regimens were also studied. In a first intensive phase, a combination of isoniazid and pyrazinamide was administered daily for 1-3 mth. The second phase consisted of daily isoniazid alone or isoniazid and pyrazinamide twice a wk. The longer the initial phase of daily combined chemotherapy the better the final result of the 2 phase treatment. Whether the first phase lasted 1, 2 or 3 mth, the twice weekly isoniazid plus pyrazinamide regimen is, in the second phase, more effective than the daily isoniazid regimen. After 3 mth of continuous treatment, twice weekly isoniazid plus pyrazinamide gave 100% negative cultures.
|Translated title of the contribution||Pyrazinamide in short course chemotherapy of murine tuberculosis|
|Number of pages||14|
|Journal||Revue Francaise des Maladies Respiratoires|
|State||Published - Jan 1 1975|
ASJC Scopus subject areas