Pyoderma Gangrenosum, Altered Delayed Hypersensitivity, and Polyarthritis

Gerald S. Lazarus, Lowell A. Goldsmith, Ross E. Rocklin, Robert S. Pinals, Jean Pierre Buisseret, John R. David, Cdr Will Draper

Research output: Contribution to journalArticlepeer-review

Abstract

Four patients with pyoderma gangrenosum were found to have an abnormality of delayed hypersensitivity that was characterized by cutaneous anergy and dissociation between macrophage inhibitory factor production and blastogenic response in vitro. Three of these four patients had a rheumatoid-like polyarthritis. One patient responded to conservative therapy but three required high doses of corticosteroids for healing of the ulcers.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalArchives of dermatology
Volume105
Issue number1
DOIs
StatePublished - Jan 1972
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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