Pylorus preserving pancreatoduodenectomy: An overview

P. A. Grace, H. A. Pitt, W. P. Longmire

Research output: Contribution to journalReview articlepeer-review

169 Scopus citations


Pylorus preserving pancreatoduodenectomy (PPPD) was reintroduced 12 years ago. Since that time, over 400 patients have undergone PPPD with approximately 41 per cent having chronic pancreatitis and 54 per cent having pancreatic and other periampullary malignancies. Reported 5‐year survivals in this latter group have been comparable to those achieved by the classic Whipple procedure. The postoperative mortality rate in 339 reported patients has been 3·8 per cent. Postoperative morbidity, including delayed gastric emptying, has been similar to that of the classic Whipple operation. However, PPPD has been associated with fewer late problems with dumping, diarrhoea, delayed gastric emptying (8·6 per cent), and marginal ulceration (3·6 per cent). Moreover, most patients undergoing PPPD have been able to return to their preoperative and preillness weight. The additional advantage of decreased operative time makes PPPD an attractive alternative to the classic pancreatoduodenectomy.

Original languageEnglish (US)
Pages (from-to)968-974
Number of pages7
JournalBritish Journal of Surgery
Issue number9
StatePublished - Sep 1990


  • Pancreatoduodenectomy
  • ampullary carcinoma
  • chronic pancreatitis
  • distal bile duct carcinoma
  • duodenal carcinoma
  • pancreatic carcinoma

ASJC Scopus subject areas

  • Surgery


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