Pyloric electrical stimulation reduces food intake by inhibiting gastric motility in dogs

Xiaohong Xu, Hongbing Zhu, Jiande Chen

Research output: Contribution to journalArticle

Abstract

Background & Aims: The pylorus plays an important role in regulating gastric emptying. The aim of this study was to investigate the therapeutic potential of pyloric electrical stimulation (PES) for obesity in dogs. Methods: The study was composed of 3 separate experiments. The first experiment was designed to study the effects of PES with various parameters on gastric emptying and gastric slow waves in 5 sessions. The second experiment was used to test the effects of PES on antral contractions. The acute effect of PES on food intake was studied in the third experiment. Results: (1) Pyloric myoelectrical recording showed dual frequencies. The lower frequency was identical to the frequency of the gastric slow waves, and the higher frequency was similar to that of the intestinal slow waves. (2) Gastric emptying was significantly delayed with PES, and the delay in gastric emptying was significantly and negatively correlated with stimulation energy (r = -.673; P

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalGastroenterology
Volume128
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

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Electric Stimulation
Gastric Emptying
Stomach
Eating
Dogs
Radio Waves
Pylorus
Obesity
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pyloric electrical stimulation reduces food intake by inhibiting gastric motility in dogs. / Xu, Xiaohong; Zhu, Hongbing; Chen, Jiande.

In: Gastroenterology, Vol. 128, No. 1, 01.2005, p. 43-50.

Research output: Contribution to journalArticle

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