Putting the Brakes on Cytokinesis with α-Actinin

Elizabeth M. Reichl, Douglas N. Robinson

Research output: Contribution to journalShort survey


Although signal transduction pathways provide spatiotemporal control of cytokinesis, additional regulation likely occurs through complex cytoskeletal network interactions. In this issue of Developmental Cell, Mukhina et al. (2007) show that myosin-II modulates the cortical lifetime of the actin crosslinker α-actinin, which in turn tunes actin filament dynamics, thereby controlling furrow ingression.

Original languageEnglish (US)
Pages (from-to)460-462
Number of pages3
JournalDevelopmental Cell
Issue number4
StatePublished - Oct 9 2007


ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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