Putting the Alzheimer's cognitive test to the test II: Rasch Measurement Theory

Jeremy Hobart, Stefan Cano, Holly Posner, Ola Selnes, Yaakov Stern, Ronald Thomas, John Zajicek

Research output: Contribution to journalArticle

Abstract

Background: The Alzheimer's Disease Assessment Scale - Cognitive Behavior section (ADAS-Cog) is the most widely used measure of cognitive performance in AD clinical trials. This key role has rightly brought its performance under increased scrutiny with recent research using traditional psychometric methods, questioning the ADAS-Cog's ability to adequately measure early-stage disease. However, given the limitations of traditional psychometric approaches, herein we use the more sophisticated Rasch Measurement Theory (RMT) methods to fully examine the strengths and weaknesses of the ADAS-Cog, and identify potential paths toward its improvement. Methods: We analyzed AD Neuroimaging Initiative (ADNI) ADAS-Cog data (675 measurements across four time-points over 2 years) from the AD participants. RMT analysis was undertaken to examine three broad areas: adequacy of scale-to-sample targeting; degree to which, taken together, the ADAS-Cog items adequately perform as a measuring instrument; and how well the scale measured the subjects in the current sample. Results: The 11 ADAS-Cog components mapped-out a measurement continuum, worked together adequately, and were stable across different time-points and samples. However, the scale did not prove to be a good match to the patient sample supporting previous research. RMT analysis also identified problematic "gaps" and "bunching" of the components across the continuum. Conclusion: Although the ADAS-Cog has the building blocks of a good measurement instrument, this sophisticated analysis confirms limitations with potentially serious implications for clinical trials. Importantly, and unlike traditional psychometric methods, our RMT analysis has provided important clues aimed at solving the measurement problems of the ADAS-Cog.

Original languageEnglish (US)
Pages (from-to)S4-S9
JournalAlzheimer's and Dementia
Volume9
Issue number1 SUPPL.
DOIs
StatePublished - Feb 2013

Keywords

  • Alzheimer's disease
  • Clinical trials
  • Psychometrics
  • Rasch Measurement Theory
  • Reliability
  • Validity

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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  • Cite this

    Hobart, J., Cano, S., Posner, H., Selnes, O., Stern, Y., Thomas, R., & Zajicek, J. (2013). Putting the Alzheimer's cognitive test to the test II: Rasch Measurement Theory. Alzheimer's and Dementia, 9(1 SUPPL.), S4-S9. https://doi.org/10.1016/j.jalz.2012.08.005