Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity

Nathan Archer, Migena N. Dilolli, Lloyd S Miller

Research output: Contribution to journalComment/debate

Abstract

Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-del) is a psoriasis risk factor linked to the major psoriasis risk gene HLA-C*06. Niehues et al. demonstrate that LCE3B/C-del leads to increased keratinocyte LCE3A expression. They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regulate epidermal barrier integrity. These findings implicate LCE proteins in psoriasis pathogenesis via a new functional role.

Original languageEnglish (US)
Pages (from-to)2257-2259
Number of pages3
JournalJournal of Investigative Dermatology
Volume137
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

Psoriasis
Genes
HLA-C Antigens
Proteins
Keratinocytes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Pushing the Envelope in Psoriasis : Late Cornified Envelope Proteins Possess Antimicrobial Activity. / Archer, Nathan; Dilolli, Migena N.; Miller, Lloyd S.

In: Journal of Investigative Dermatology, Vol. 137, No. 11, 01.11.2017, p. 2257-2259.

Research output: Contribution to journalComment/debate

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AB - Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-del) is a psoriasis risk factor linked to the major psoriasis risk gene HLA-C*06. Niehues et al. demonstrate that LCE3B/C-del leads to increased keratinocyte LCE3A expression. They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regulate epidermal barrier integrity. These findings implicate LCE proteins in psoriasis pathogenesis via a new functional role.

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