Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity

Nathan K. Archer; Migena N. Dilolli; Lloyd S. Miller

doi:10.1016/j.jid.2017.08.026

Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity

Nathan K. Archer, Migena N. Dilolli, Lloyd S. Miller

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-del) is a psoriasis risk factor linked to the major psoriasis risk gene HLA-C*06. Niehues et al. demonstrate that LCE3B/C-del leads to increased keratinocyte LCE3A expression. They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regulate epidermal barrier integrity. These findings implicate LCE proteins in psoriasis pathogenesis via a new functional role.

Original language	English (US)
Pages (from-to)	2257-2259
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	137
Issue number	11
DOIs	https://doi.org/10.1016/j.jid.2017.08.026
State	Published - Nov 2017

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

Access to Document

10.1016/j.jid.2017.08.026

Cite this

@article{1dc6b1d541f749bf9f8921ffb7b5b3bb,

title = "Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity",

abstract = "Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-del) is a psoriasis risk factor linked to the major psoriasis risk gene HLA-C*06. Niehues et al. demonstrate that LCE3B/C-del leads to increased keratinocyte LCE3A expression. They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regulate epidermal barrier integrity. These findings implicate LCE proteins in psoriasis pathogenesis via a new functional role.",

author = "Archer, {Nathan K.} and Dilolli, {Migena N.} and Miller, {Lloyd S.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = nov,

doi = "10.1016/j.jid.2017.08.026",

language = "English (US)",

volume = "137",

pages = "2257--2259",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "Nature Publishing Group",

number = "11",

}

TY - JOUR

T1 - Pushing the Envelope in Psoriasis

T2 - Late Cornified Envelope Proteins Possess Antimicrobial Activity

AU - Archer, Nathan K.

AU - Dilolli, Migena N.

AU - Miller, Lloyd S.

PY - 2017/11

Y1 - 2017/11

N2 - Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-del) is a psoriasis risk factor linked to the major psoriasis risk gene HLA-C*06. Niehues et al. demonstrate that LCE3B/C-del leads to increased keratinocyte LCE3A expression. They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regulate epidermal barrier integrity. These findings implicate LCE proteins in psoriasis pathogenesis via a new functional role.

AB - Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-del) is a psoriasis risk factor linked to the major psoriasis risk gene HLA-C*06. Niehues et al. demonstrate that LCE3B/C-del leads to increased keratinocyte LCE3A expression. They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regulate epidermal barrier integrity. These findings implicate LCE proteins in psoriasis pathogenesis via a new functional role.

UR - http://www.scopus.com/inward/record.url?scp=85032032584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032032584&partnerID=8YFLogxK

U2 - 10.1016/j.jid.2017.08.026

DO - 10.1016/j.jid.2017.08.026

M3 - Comment/debate

C2 - 29055413

AN - SCOPUS:85032032584

SN - 0022-202X

VL - 137

SP - 2257

EP - 2259

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 11

ER -

Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this