Pushed out of a tough crowd: Centrosome aberrations promote invasiveness

Lauren T. Evans, Andrew Holland

Research output: Contribution to journalArticle

Abstract

Centrosome defects are observed in a broad array of solid and liquid tumors and are associated with advanced disease and poor patient prognosis. Unexpectedly, centrosome aberrations are present in only a subset of cells within a tumor and are poorly tolerated in non-transformed cells, raising the conundrum of why centrosome aberrations are maintained during tumor evolution. New work by Ganier et al published in The EMBO Journal shows that centrosome defects can function in a non-cell-autonomous manner to force mitotic cells out of an epithelium, providing a plausible mechanism to promote dissemination of metastatic cells.

Original languageEnglish (US)
JournalEMBO Journal
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Centrosome
Aberrations
Tumors
Defects
Neoplasms
Epithelium
Liquids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Pushed out of a tough crowd : Centrosome aberrations promote invasiveness. / Evans, Lauren T.; Holland, Andrew.

In: EMBO Journal, 01.01.2018.

Research output: Contribution to journalArticle

@article{33cc1c8cd6294d7b9bfad8346f702471,
title = "Pushed out of a tough crowd: Centrosome aberrations promote invasiveness",
abstract = "Centrosome defects are observed in a broad array of solid and liquid tumors and are associated with advanced disease and poor patient prognosis. Unexpectedly, centrosome aberrations are present in only a subset of cells within a tumor and are poorly tolerated in non-transformed cells, raising the conundrum of why centrosome aberrations are maintained during tumor evolution. New work by Ganier et al published in The EMBO Journal shows that centrosome defects can function in a non-cell-autonomous manner to force mitotic cells out of an epithelium, providing a plausible mechanism to promote dissemination of metastatic cells.",
author = "Evans, {Lauren T.} and Andrew Holland",
year = "2018",
month = "1",
day = "1",
doi = "10.15252/embj.201899422",
language = "English (US)",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Pushed out of a tough crowd

T2 - Centrosome aberrations promote invasiveness

AU - Evans, Lauren T.

AU - Holland, Andrew

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Centrosome defects are observed in a broad array of solid and liquid tumors and are associated with advanced disease and poor patient prognosis. Unexpectedly, centrosome aberrations are present in only a subset of cells within a tumor and are poorly tolerated in non-transformed cells, raising the conundrum of why centrosome aberrations are maintained during tumor evolution. New work by Ganier et al published in The EMBO Journal shows that centrosome defects can function in a non-cell-autonomous manner to force mitotic cells out of an epithelium, providing a plausible mechanism to promote dissemination of metastatic cells.

AB - Centrosome defects are observed in a broad array of solid and liquid tumors and are associated with advanced disease and poor patient prognosis. Unexpectedly, centrosome aberrations are present in only a subset of cells within a tumor and are poorly tolerated in non-transformed cells, raising the conundrum of why centrosome aberrations are maintained during tumor evolution. New work by Ganier et al published in The EMBO Journal shows that centrosome defects can function in a non-cell-autonomous manner to force mitotic cells out of an epithelium, providing a plausible mechanism to promote dissemination of metastatic cells.

UR - http://www.scopus.com/inward/record.url?scp=85044849384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044849384&partnerID=8YFLogxK

U2 - 10.15252/embj.201899422

DO - 10.15252/embj.201899422

M3 - Article

C2 - 29622546

AN - SCOPUS:85044849384

JO - EMBO Journal

JF - EMBO Journal

SN - 0261-4189

ER -