Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccine

Cevayir Coban, Ken J. Ishii, David J Sullivan, Nirbhay Kumar

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Abstract

Hemozoin (malaria pigment) has been implicated in the modulation of immune responses during malaria infection. This study was designed to evaluate the effect of purified hemozoin on the in vitro activation of myeloid dendritic cells. Our study also revealed that in addition to enhancing the maturation of dendritic cells, hemozoin also greatly promotes immunoglobulin G2a antibody responses when coadministered with a DNA vaccine plasmid encoding Pfs25, a Plasmodium falciparum transmission-blocking antigen.

Original languageEnglish (US)
Pages (from-to)3939-3943
Number of pages5
JournalInfection and Immunity
Volume70
Issue number7
DOIs
Publication statusPublished - 2002

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ASJC Scopus subject areas

  • Immunology

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