Purified Duck Embryo Rabies Vaccine: An Accelerated Schedule for Preexposure Immunization Against Rabies

Kenrad E. Nelson, Murray D. Batt, Vicharn Vithayasai, Sanit Makornkawkayoon, Kampol Panas-Amporn, John T. Anderson

Research output: Contribution to journalArticle

Abstract

Seroconversion and adverse reaction rates were studied in 92 persons given four or five doses in a two-week period of duck embryo rabies vaccine (DEV) or duck embryo rabies vaccine purified by ultracentrifugation (P-DEV). Mouse-neutralizing antibodies developed in 78 of 92 (84.8%) persons in these accelerated schedules. There were no significant differences in the frequency of antibody conversion or in geometric mean titers of antibody between persons given either vaccine. However, local and systemic adverse reactions were substantially less common with P-DEV. These data suggest that four or five doses of DEV or P-DEV given in a two-week course can be used for preexposure prophylaxis in situations where the more drawn-out regimens would result in continuation of a high-risk of rabies exposure. The antibody response of persons given this more accelerated regimen must be determined. (JAMA 238:218-220, 1977).

Original languageEnglish (US)
Pages (from-to)218-220
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Volume238
Issue number3
DOIs
StatePublished - Jul 18 1977
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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