Pure red cell aplasia due to parvovirus B19 infection in solid organ transplantation

Nasimul Ahsan, Michael J. Holman, Christopher D. Gocke, James A. Groff, Harold C. Yang

Research output: Contribution to journalArticle

Abstract

Human parvovirus B19 disease is an infrequent but recognized rare cause of anemia in immunocompromised patients. A few cases of parvovirus B19 infections have been reported in transplant recipients, of those only four patients underwent renal transplantation. The primary immunosuppressive therapy in these patients included prednisone with either cyclosporine or tacrolimus. In one patient the disease was self-limiting, while in three others the hematocrit improved following 10-15 d of treatment with commercial intravenous immunoglobulin (IVIG). Herein, we report the fifth case of pure red cell aplasia due to parvovirus B19 infection in a renal transplant recipient who responded to a 5-d course of IVIG. To our knowledge, this is the first case of parvovirus B19 infection in a patient with solid-organ transplantation whose immunosuppressive regimen in eluded both mycophenolate mofetil and tacrolimus and in whom an excellent clinical response was achieved with a short course of IVIG infusion.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalClinical Transplantation
Volume11
Issue number4
StatePublished - Aug 1 1997

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Keywords

  • Anemia
  • Intravenous immunoglobulin
  • Parvovirus B19
  • Transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Ahsan, N., Holman, M. J., Gocke, C. D., Groff, J. A., & Yang, H. C. (1997). Pure red cell aplasia due to parvovirus B19 infection in solid organ transplantation. Clinical Transplantation, 11(4), 265-270.