Punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline

Erika Matunis, John Tran, Pierre Gönczy, Kim Caldwell, Stephen DiNardo

Research output: Contribution to journalArticle

Abstract

To identify regulators of stem cell lineages, we are focusing on spermatogenesis in Drosophila. In spermatogenesis, each germline stem cell divides asymmetrically, renewing itself and producing a transiently amplifying daughter, which divides four times. By screening for mutants in which daughter cells fail to stop dividing, we find that the TGF-β signal transducers schnurri and punt are required to limit transient amplification of germ cells. Mosaic analysis demonstrates that punt and schnurri act within somatic cyst cells that surround germ cells, rather than in germ cells. Thus, a cyst-cell-derived signal restricts germ cell proliferation and this signal is initiated by input from a member of the TGF-β superfamily. Thus, a signal relay regulates progression through the germline stem cell lineage.

Original languageEnglish (US)
Pages (from-to)4383-4391
Number of pages9
JournalDevelopment
Volume124
Issue number21
StatePublished - 1997
Externally publishedYes

Fingerprint

Germ Cells
Stem Cells
Cell Lineage
Spermatogenesis
Cysts
Transducers
Drosophila
Cell Proliferation

Keywords

  • Drosophila
  • Germline
  • punt
  • schnurri
  • Spermatogenesis
  • Stem cells

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline. / Matunis, Erika; Tran, John; Gönczy, Pierre; Caldwell, Kim; DiNardo, Stephen.

In: Development, Vol. 124, No. 21, 1997, p. 4383-4391.

Research output: Contribution to journalArticle

Matunis, Erika ; Tran, John ; Gönczy, Pierre ; Caldwell, Kim ; DiNardo, Stephen. / Punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline. In: Development. 1997 ; Vol. 124, No. 21. pp. 4383-4391.
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