PUMA induces the rapid apoptosis of colorectal cancer cells

Jian Yu, Lin Zhang, Paul M. Hwang, Kenneth W. Kinzler, Bert Vogelstein

Research output: Contribution to journalArticle

Abstract

Through global profiling of genes that were expressed soon after p53 expression, we identified a novel gene termed PUMA (p53 upregulated modulator of apoptosis). The protein encoded by PUMA was found to be exclusively mitochondrial and to bind to Bcl-2 and Bcl-XL through a BH3 domain. Exogenous expression of PUMA resulted in an extremely rapid and profound apoptosis that occurred much earlier than that resulting from exogenous expression of p53. Based on its unique expression patterns, p53 dependence, and biochemical properties, PUMA may be a direct mediator of p53-associated apoptosis.

Original languageEnglish (US)
Pages (from-to)673-682
Number of pages10
JournalMolecular cell
Volume7
Issue number3
DOIs
StatePublished - Mar 1 2001

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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